PMID- 19895766
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20221207
IS  - 1938-4114 (Electronic)
IS  - 1937-1888 (Print)
IS  - 1937-1888 (Linking)
VI  - 70
IP  - 6
DP  - 2009 Nov
TI  - Drinking histories in alcohol-use-disordered youth: preliminary findings on 
      relationships to platelet serotonin transporter expression with genotypes of the 
      serotonin transporter.
PG  - 899-907
AB  - OBJECTIVE: The serotonin (5-HT) transporter (5-HTT) is thought to play a key role 
      in the onset of alcohol use, with potential behavioral and biological mechanisms 
      mediated by the level of 5-HT in the synapse and in cerebral spinal fluid. 
      Although 5-HT dysregulation has been related to poor impulse control, the 
      biological mechanism is unknown, although functional control of the serotonergic 
      system has been shown to be regulated in part by differential expression of the 
      5-HTT. The gene responsible for encoding 5-HTT has a functional polymorphism at 
      the 5'-regulatory promoter region, which results in two forms: long (L) and short 
      (S). The LL genotype is hypothesized to play a key role in the early onset of 
      alcohol use and may be related to poor impulse control. The objective of this 
      pilot study is to determine whether adolescents with a current alcohol-use 
      disorder (AUD) (N = 21) have platelet measures of the 5-HTT functioning that are 
      related to 5-HTT genotype and poor impulse control. Specifically, we wanted to 
      examine the relationships between the following: platelet 5-HTT and 5-HTT 
      genotype; platelet 5-HTT parameters and age at onset, as well as duration of 
      drinking; and 5-HTT genotype and impulse control. METHOD: Adolescents with 
      current AUD were recruited from the community to participate in a cross-section 
      pilot study. RESULTS: Our main findings showed significantly higher paroxetine 
      binding (density of 5-HTT) in LL genotype versus S carriers (SS or SL genotypes); 
      also, the LL group had a significantly earlier age at onset of drinking and 
      longer duration of drinking, and poorer impulse control. CONCLUSIONS: These 
      findings provide partial support for the hypothesis that, among currently 
      drinking adolescents with an AUD, differential expression of 5-HTT may play an 
      important role in the onset of adolescent AUD.
FAU - Dawes, Michael A
AU  - Dawes MA
AD  - Department of Psychiatry, University of Texas Health Science Center at San 
      Antonio, San Antonio, TX 78229-3900, USA. dawes@uthscsa.edu
FAU - Roache, John D
AU  - Roache JD
FAU - Javors, Martin A
AU  - Javors MA
FAU - Bergeson, Susan E
AU  - Bergeson SE
FAU - Richard, Dawn M
AU  - Richard DM
FAU - Mathias, Charles W
AU  - Mathias CW
FAU - Ait-Daoud, Nassima
AU  - Ait-Daoud N
FAU - Dougherty, Donald M
AU  - Dougherty DM
FAU - Johnson, Bankole A
AU  - Johnson BA
LA  - eng
GR  - R01 MH077684/MH/NIMH NIH HHS/United States
GR  - R01-MH-077684/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Stud Alcohol Drugs
JT  - Journal of studies on alcohol and drugs
JID - 101295847
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 41VRH5220H (Paroxetine)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Alcohol Drinking/*genetics
MH  - Alcohol-Related Disorders/*genetics
MH  - Blood Platelets/metabolism
MH  - Cross-Sectional Studies
MH  - Disruptive, Impulse Control, and Conduct Disorders/complications/genetics
MH  - Female
MH  - Gene Expression
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Paroxetine/metabolism
MH  - Pilot Projects
MH  - Polymorphism, Genetic
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Selective Serotonin Reuptake Inhibitors/metabolism
MH  - Young Adult
PMC - PMC2776120
EDAT- 2009/11/10 06:00
MHDA- 2010/01/27 06:00
PMCR- 2010/11/01
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - 899 [pii]
AID - 10.15288/jsad.2009.70.899 [doi]
PST - ppublish
SO  - J Stud Alcohol Drugs. 2009 Nov;70(6):899-907. doi: 10.15288/jsad.2009.70.899.