PMID- 19896518
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20211020
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 2
DP  - 2010 Feb
TI  - Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral 
      and cell-mediated immune responses.
PG  - 128-35
LID - 10.1016/j.humimm.2009.11.002 [doi]
AB  - Human leukocyte antigen (HLA) genes play a critical role in host immunity, 
      including vaccine responses. HLA molecules present antigenic peptides to T cells 
      and provide inhibitory signals to NK cells, and polymorphisms within HLA genes 
      allow binding and presentation of a diverse array of self and foreign peptides. 
      Heterozygosity across HLA alleles has been found to play a positive role in host 
      defense for a variety of infections. Homozygosity within one or more HLA loci may 
      restrict this epitope repertoire and limit T-cell responses to infection or 
      vaccination. Here we report that homozygosity within the HLA DPB1 locus is 
      associated with increased levels of rubella-specific IgG, an effect driven by a 
      common allele DPB1*0401. We also show that homozygosity within different HLA 
      class I and class II loci is correlated with variations (but not necessarily 
      decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus 
      stimulation.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Kennedy, Richard B
AU  - Kennedy RB
AD  - Mayo Clinic, Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
FAU - Vierkant, Robert A
AU  - Vierkant RA
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
GR  - UL1 RR024150-01/RR/NCRR NIH HHS/United States
GR  - R01 AI033144/AI/NIAID NIH HHS/United States
GR  - R01 AI048793-03/AI/NIAID NIH HHS/United States
GR  - R01 AI033144-15/AI/NIAID NIH HHS/United States
GR  - R37 AI048793/AI/NIAID NIH HHS/United States
GR  - AI 48793/AI/NIAID NIH HHS/United States
GR  - AI 33144/AI/NIAID NIH HHS/United States
GR  - R01 AI048793/AI/NIAID NIH HHS/United States
GR  - UL1 RR024150/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091105
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies, Viral)
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
RN  - 0 (Rubella Vaccine)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Viral/blood/immunology
MH  - Child
MH  - Cytokines/biosynthesis/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - HLA Antigens/*genetics/immunology
MH  - Homozygote
MH  - Humans
MH  - Immunity, Cellular/*genetics
MH  - Immunity, Humoral/*genetics
MH  - Male
MH  - Rubella Vaccine/*genetics/*immunology
MH  - Rubella virus/immunology
MH  - Young Adult
PMC - PMC2815167
MID - NIHMS157909
EDAT- 2009/11/10 06:00
MHDA- 2010/04/08 06:00
PMCR- 2011/02/01
CRDT- 2009/11/10 06:00
PHST- 2009/05/14 00:00 [received]
PHST- 2009/10/23 00:00 [revised]
PHST- 2009/11/02 00:00 [accepted]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
PHST- 2011/02/01 00:00 [pmc-release]
AID - S0198-8859(09)00633-8 [pii]
AID - 10.1016/j.humimm.2009.11.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Feb;71(2):128-35. doi: 10.1016/j.humimm.2009.11.002. Epub 2009 
      Nov 5.