PMID- 19897226
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20220330
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 78
IP  - 2
DP  - 2010 Jan
TI  - Analysis of POPs in human samples reveal a contribution of brominated dioxin of 
      up to 15% of the total dioxin TEQ.
PG  - 113-20
LID - 10.1016/j.chemosphere.2009.10.012 [doi]
AB  - Polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) were analyzed in 
      both human adipose tissue and plasma from nine individuals, from the Swedish 
      general population, using high resolution gas chromatography/high resolution mass 
      spectrometry (HRGC/HRMS). In addition, several other persistent organic 
      pollutants (POPs) were determined in the same samples, including polychlorinated 
      dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), 
      polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs). 
      Polybrominated dibenzofurans were detected in all of the human adipose tissue 
      samples confirming their presence in the Swedish population. The highest 
      concentration was found for 2,3,7,8-TeBDF, ranging from 0.27 to 2.4 pg g(-1) 
      lipid, followed by 1,2,3,7,8-PeBDF, 0.23-0.89pgg(-1) lipid, 2,3,4,7,8-PeBDF, 
      0.44-0.54 pg g(-1) lipid, and 2,7/2,8-DiBDF, 0.19-0.30 pg g(-1) lipid. No PBDDs 
      could be detected above the limit of detection (<0.02-<0.21 pg g(-1) lipid) in 
      any of the samples. The levels of PCDD/Fs were in the range 1.79-31.5pg toxic 
      equivalents (TEQ)g(-1) lipid, and PBDEs were found in the 1.16-7.46 ng g(-1) 
      lipid range. The measured chlorinated dioxins indicate decreasing human 
      concentrations in Sweden. The toxicity equivalents (TEQ) for PBDD/Fs (0.2-0.8 pg 
      TEQg(-1) lipid) were found to contribute 1-15% of the total dioxin TEQ of the 
      chlorinated dioxins and furans (5-18 pg TEQg(-1) lipid) depending on the 
      individual. Also PBDEs concentrations are decreasing compared to 1997-2000, but 
      most noteworthy a shift in BDE pattern where BDE#47 is surpassed by BDE#153. The 
      levels of PFCs are in the same range as the highest levels of the traditional 
      POPs (sum of 60 PCBs) based on volume. These findings illustrate the importance 
      of continuous monitoring of brominated compounds in both human and the 
      environment.
FAU - Ericson Jogsten, Ingrid
AU  - Ericson Jogsten I
AD  - MTM Research Center, School of Science and Technology, Orebro University, SE70182 
      Orebro, Sweden. ingrid.ericson@oru.se
FAU - Hagberg, Jessika
AU  - Hagberg J
FAU - Lindstrom, Gunilla
AU  - Lindstrom G
FAU - Bavel, Bert van
AU  - Bavel Bv
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091107
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Benzofurans)
RN  - 0 (Dioxins)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Polymers)
RN  - 0 (polychlorodibenzofuran)
RN  - 8U54U639VI (dibenzofuran)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - SBV4XY874G (Bromine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Benzofurans/analysis/blood/toxicity
MH  - Bromine/*chemistry
MH  - Dioxins/*analysis/blood/toxicity
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Halogenated Diphenyl Ethers/analysis/blood/toxicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/analysis/blood/toxicity
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/analysis/blood/toxicity
MH  - Polymers/analysis/toxicity
EDAT- 2009/11/10 06:00
MHDA- 2010/02/19 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/05/14 00:00 [received]
PHST- 2009/10/07 00:00 [revised]
PHST- 2009/10/10 00:00 [accepted]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
AID - S0045-6535(09)01205-3 [pii]
AID - 10.1016/j.chemosphere.2009.10.012 [doi]
PST - ppublish
SO  - Chemosphere. 2010 Jan;78(2):113-20. doi: 10.1016/j.chemosphere.2009.10.012. Epub 
      2009 Nov 7.