PMID- 19903473
OWN - NLM
STAT- MEDLINE
DCOM- 20100121
LR  - 20171116
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 584
IP  - 1
DP  - 2010 Jan 4
TI  - Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in 
      vitro and in vivo.
PG  - 111-8
LID - 10.1016/j.febslet.2009.11.007 [doi]
AB  - Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central 
      event in the pathogenesis of allergic disorders. The present report shows that 
      treatment with pentagalloylglucose (PGG) resulted in a down-regulation of 
      FcepsilonRI surface expression on mucosal-type murine bone marrow-derived mast 
      cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of 
      mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a 
      food-allergy mouse model and suppressed the up-regulated FcepsilonRI surface 
      expression on mast cells derived from the food-allergy mouse colon. These 
      findings on PGG suggest its therapeutic potential for allergic diseases through 
      suppressing the FcepsilonRI surface expression.
FAU - Kageyama-Yahara, Natsuko
AU  - Kageyama-Yahara N
AD  - Division of Gastrointestinal Pathophysiology, Department of Bioscience, Institute 
      of Natural Medicine, University of Toyama, Toyama, Japan. 
      natsuko@inm.u-toyama.ac.jp
FAU - Suehiro, Yoko
AU  - Suehiro Y
FAU - Maeda, Futoshi
AU  - Maeda F
FAU - Kageyama, Shun-ichiro
AU  - Kageyama S
FAU - Fukuoka, Junya
AU  - Fukuoka J
FAU - Katagiri, Tatsuo
AU  - Katagiri T
FAU - Yamamoto, Takeshi
AU  - Yamamoto T
FAU - Kadowaki, Makoto
AU  - Kadowaki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Hydrolyzable Tannins)
RN  - 0 (Receptors, IgE)
RN  - 0 (kakkon-to)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3UI3K8W93I (pentagalloylglucose)
SB  - IM
MH  - Animals
MH  - Cell Degranulation/drug effects
MH  - Cell Membrane/drug effects/immunology
MH  - Cells, Cultured
MH  - Diarrhea/*immunology/pathology
MH  - Disease Models, Animal
MH  - Down-Regulation
MH  - Drugs, Chinese Herbal/pharmacology
MH  - Food Hypersensitivity/*immunology/pathology
MH  - Hydrolyzable Tannins/*pharmacology
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Mast Cells/*drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Paeonia/chemistry
MH  - Receptors, IgE/*antagonists & inhibitors/immunology
EDAT- 2009/11/12 06:00
MHDA- 2010/01/22 06:00
CRDT- 2009/11/12 06:00
PHST- 2009/07/03 00:00 [received]
PHST- 2009/10/30 00:00 [revised]
PHST- 2009/11/03 00:00 [accepted]
PHST- 2009/11/12 06:00 [entrez]
PHST- 2009/11/12 06:00 [pubmed]
PHST- 2010/01/22 06:00 [medline]
AID - S0014-5793(09)00899-0 [pii]
AID - 10.1016/j.febslet.2009.11.007 [doi]
PST - ppublish
SO  - FEBS Lett. 2010 Jan 4;584(1):111-8. doi: 10.1016/j.febslet.2009.11.007.