PMID- 19904028
OWN - NLM
STAT- MEDLINE
DCOM- 20100219
LR  - 20240320
IS  - 1361-6560 (Electronic)
IS  - 0031-9155 (Print)
IS  - 0031-9155 (Linking)
VI  - 54
IP  - 23
DP  - 2009 Dec 7
TI  - Bayesian PET image reconstruction incorporating anato-functional joint entropy.
PG  - 7063-75
LID - 10.1088/0031-9155/54/23/002 [doi]
AB  - We developed a maximum a posterior (MAP) reconstruction method for positron 
      emission tomography (PET) image reconstruction incorporating magnetic resonance 
      (MR) image information, with the joint entropy between the PET and MR image 
      features serving as the regularization constraint. A non-parametric method was 
      used to estimate the joint probability density of the PET and MR images. Using 
      realistically simulated PET and MR human brain phantoms, the quantitative 
      performance of the proposed algorithm was investigated. Incorporation of the 
      anatomic information via this technique, after parameter optimization, was seen 
      to dramatically improve the noise versus bias tradeoff in every region of 
      interest, compared to the result from using conventional MAP reconstruction. In 
      particular, hot lesions in the FDG PET image, which had no anatomical 
      correspondence in the MR image, also had improved contrast versus noise 
      tradeoff.Corrections were made to figures 3, 4 and 6, and to the second paragraph 
      of section 3.1 on 13 November 2009. The corrected electronic version is identical 
      to the print version.
FAU - Tang, Jing
AU  - Tang J
AD  - Department of Radiology, The Johns Hopkins University, Baltimore, MD 21287, USA. 
      jtang18@jhmi.edu
FAU - Rahmim, Arman
AU  - Rahmim A
LA  - eng
GR  - S10 RR023623/RR/NCRR NIH HHS/United States
GR  - S10 RR023623-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091111
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
SB  - IM
MH  - Algorithms
MH  - Bayes Theorem
MH  - Brain/diagnostic imaging
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging
MH  - Phantoms, Imaging
MH  - Positron-Emission Tomography/*methods
PMC - PMC3104509
MID - NIHMS291810
EDAT- 2009/11/12 06:00
MHDA- 2010/02/20 06:00
PMCR- 2011/05/31
CRDT- 2009/11/12 06:00
PHST- 2009/11/12 06:00 [entrez]
PHST- 2009/11/12 06:00 [pubmed]
PHST- 2010/02/20 06:00 [medline]
PHST- 2011/05/31 00:00 [pmc-release]
AID - S0031-9155(09)28656-8 [pii]
AID - 10.1088/0031-9155/54/23/002 [doi]
PST - ppublish
SO  - Phys Med Biol. 2009 Dec 7;54(23):7063-75. doi: 10.1088/0031-9155/54/23/002. Epub 
      2009 Nov 11.