PMID- 19905983
OWN - NLM
STAT- MEDLINE
DCOM- 20100217
LR  - 20131121
IS  - 1029-2470 (Electronic)
IS  - 1029-2470 (Linking)
VI  - 43
IP  - 12
DP  - 2009 Dec
TI  - Lignin-derived lignophenols attenuate oxidative and inflammatory damage to the 
      kidney in streptozotocin-induced diabetic rats.
PG  - 1205-13
LID - 10.3109/10715760903247264 [doi]
AB  - This study investigated the effects of lignin-derived lignophenols (LPs) on the 
      oxidative stress and infiltration of macrophages in the kidney of streptozotocin 
      (STZ)-induced diabetic rats. The diabetic rats were divided into four groups with 
      0%, 0.11%, 0.33% and 1.0% LP diets. The vehicle-injected controls were given a 
      commercial diet. At 5 weeks, superoxide (O(2)(-)) production, macrophage 
      kinetics, the degree of fibrosis in glomeruli and mRNA expression for monocyte 
      chemoattractant protein-1 (MCP-1) were examined. The NADPH-stimulated O(2)(-) 
      levels in the kidney of the diabetic rats treated with 1.0% LP were significantly 
      lower than those in untreated diabetic rats. The number of macrophages, levels of 
      MCP-1 mRNA expression and degree of glomerular fibrosis increased in untreated LP 
      and these levels were significantly lower in 1.0%LP-treated rats. The results 
      suggested that LPs suppress the excess oxidative stress, the infiltration and 
      activation of macrophages and the glomerular expansion in STZ-induced diabetic 
      kidneys.
FAU - Sato, Shin
AU  - Sato S
AD  - Department of Nutrition, Faculty of Health Sciences, Aomori University of Health 
      and Welfare, Aomori 030-8505, Japan. s_sato3@auhw.ac.jp
FAU - Mukai, Yuuka
AU  - Mukai Y
FAU - Yamate, Jyoji
AU  - Yamate J
FAU - Norikura, Toshio
AU  - Norikura T
FAU - Morinaga, Yae
AU  - Morinaga Y
FAU - Mikame, Keigo
AU  - Mikame K
FAU - Funaoka, Masamitsu
AU  - Funaoka M
FAU - Fujita, Shuzo
AU  - Fujita S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Free Radic Res
JT  - Free radical research
JID - 9423872
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Phenols)
RN  - 5W494URQ81 (Streptozocin)
RN  - 9005-53-2 (Lignin)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/genetics
MH  - Diabetes Mellitus, Experimental/complications/*metabolism
MH  - Gene Expression Regulation/drug effects
MH  - Inflammation/drug therapy/metabolism
MH  - Kidney Diseases/complications/*drug therapy/*metabolism/pathology
MH  - Lignin/chemistry/*therapeutic use
MH  - Male
MH  - Molecular Structure
MH  - Oxidative Stress/*drug effects
MH  - Phenols/chemistry/*therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin
EDAT- 2009/11/13 06:00
MHDA- 2010/02/18 06:00
CRDT- 2009/11/13 06:00
PHST- 2009/11/13 06:00 [entrez]
PHST- 2009/11/13 06:00 [pubmed]
PHST- 2010/02/18 06:00 [medline]
AID - 10.3109/10715760903247264 [pii]
AID - 10.3109/10715760903247264 [doi]
PST - ppublish
SO  - Free Radic Res. 2009 Dec;43(12):1205-13. doi: 10.3109/10715760903247264.