PMID- 19906448
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20100201
IS  - 1878-108X (Electronic)
IS  - 0166-2236 (Linking)
VI  - 33
IP  - 1
DP  - 2010 Jan
TI  - Post-transcriptional control of neurofilaments: New roles in development, 
      regeneration and neurodegenerative disease.
PG  - 27-37
LID - 10.1016/j.tins.2009.10.002 [doi]
AB  - Neurofilament (NF) protein expression is coupled to axon development and the 
      maintenance of neuronal homeostasis. Here, we present evidence that this tight 
      regulation depends critically on post-transcriptionally regulated changes in NF 
      mRNA transport, translation and stability. Recent studies have shown that 
      post-transcriptional mechanisms modulate increases in NF gene transcription 
      during axon regeneration to yield the final pattern of NF protein expression. 
      Other recent work has found that post-transcriptional control of NFs shares 
      elements with that of other axonal proteins and that its dysregulation 
      contributes to amyotrophic lateral sclerosis. Such studies herald a novel 
      approach to understanding how neurons coordinate the expressions of functionally 
      related proteins and provide new insights into how the dysregulation of this 
      control can lead to disease.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Szaro, Ben G
AU  - Szaro BG
AD  - Department of Biological Sciences and the Neuroscience Research Center, 
      University at Albany, SUNY, 1400 Washington Avenue, Albany, NY 12222, USA. 
      bgs86@albany.edu
FAU - Strong, Michael J
AU  - Strong MJ
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20091110
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (Neurofilament Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Gene Expression
MH  - Gene Expression Regulation
MH  - Humans
MH  - Nerve Regeneration/*physiology
MH  - Neurodegenerative Diseases/genetics/*metabolism/*physiopathology
MH  - Neurofilament Proteins/*physiology
MH  - RNA Processing, Post-Transcriptional/*physiology
MH  - RNA, Messenger/genetics
RF  - 109
EDAT- 2009/11/13 06:00
MHDA- 2010/04/08 06:00
CRDT- 2009/11/13 06:00
PHST- 2009/04/26 00:00 [received]
PHST- 2009/09/21 00:00 [revised]
PHST- 2009/10/06 00:00 [accepted]
PHST- 2009/11/13 06:00 [entrez]
PHST- 2009/11/13 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
AID - S0166-2236(09)00171-4 [pii]
AID - 10.1016/j.tins.2009.10.002 [doi]
PST - ppublish
SO  - Trends Neurosci. 2010 Jan;33(1):27-37. doi: 10.1016/j.tins.2009.10.002. Epub 2009 
      Nov 10.