PMID- 19906969
OWN - NLM
STAT- MEDLINE
DCOM- 20091202
LR  - 20231213
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 45
DP  - 2009 Nov 11
TI  - Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron 
      axons to the posterior region of the accessory olfactory bulb.
PG  - 14211-22
LID - 10.1523/JNEUROSCI.3948-09.2009 [doi]
AB  - The ability of sensory systems to detect and process information from the 
      environment relies on the elaboration of precise connections between sensory 
      neurons in the periphery and second order neurons in the CNS. In mice, the 
      accessory olfactory system is thought to regulate a wide variety of social and 
      sexual behaviors. The expression of the Slit receptors Robo-1 and Robo-2 in 
      vomeronasal sensory neurons (VSNs) suggests they may direct the stereotypic 
      targeting of their axons to the accessory olfactory bulb (AOB). Here, we have 
      examined the roles of Robo-1 and Robo-2 in the formation of connections by VSN 
      axons within the AOB. While Robo-1 is not necessary for the segregation of VSN 
      axons within the anterior and posterior regions of the AOB, Robo-2 is required 
      for the targeting of some basal VSN axons to the posterior region of the AOB but 
      is dispensable for the fasciculation of VSN axons. Furthermore, the specific 
      ablation of Robo-2 expression in VSNs leads to mistargeting of a portion of basal 
      VSN axons to the anterior region of the AOB, indicating that Robo-2 expression is 
      required on projecting VSN axons. Together, these results identify Robo-2 as a 
      receptor that controls the targeting of basal VSN axons to the posterior AOB.
FAU - Prince, Janet E A
AU  - Prince JE
AD  - Montreal Neurological Institute, Centre for Neuronal Survival, Montreal, Quebec 
      H3A 2B4, Canada.
FAU - Cho, Jin Hyung
AU  - Cho JH
FAU - Dumontier, Emilie
AU  - Dumontier E
FAU - Andrews, William
AU  - Andrews W
FAU - Cutforth, Tyler
AU  - Cutforth T
FAU - Tessier-Lavigne, Marc
AU  - Tessier-Lavigne M
FAU - Parnavelas, John
AU  - Parnavelas J
FAU - Cloutier, Jean-Francois
AU  - Cloutier JF
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 074549/WT_/Wellcome Trust/United Kingdom
GR  - CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Robo2 protein, mouse)
RN  - 0 (Slit1 protein, mouse)
RN  - 0 (Slit3 protein, mouse)
RN  - R6FXH13RRC (Slit homolog 2 protein)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Axons/*physiology
MH  - Intercellular Signaling Peptides and Proteins/genetics/metabolism
MH  - Membrane Proteins/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Olfactory Bulb/embryology/*growth & development/physiology
MH  - Receptors, Immunologic/genetics/*metabolism
MH  - Sensory Receptor Cells/*physiology
MH  - Synapses/physiology
MH  - Time Factors
MH  - Vomeronasal Organ/embryology/*growth & development/physiology
MH  - Roundabout Proteins
PMC - PMC2821732
MID - UKMS28239
OID - NLM: UKMS28239
EDAT- 2009/11/13 06:00
MHDA- 2009/12/16 06:00
PMCR- 2010/05/11
CRDT- 2009/11/13 06:00
PHST- 2009/11/13 06:00 [entrez]
PHST- 2009/11/13 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/05/11 00:00 [pmc-release]
AID - 29/45/14211 [pii]
AID - 3541644 [pii]
AID - 10.1523/JNEUROSCI.3948-09.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 Nov 11;29(45):14211-22. doi: 10.1523/JNEUROSCI.3948-09.2009.