PMID- 19909382
OWN - NLM
STAT- MEDLINE
DCOM- 20100115
LR  - 20091113
IS  - 1751-553X (Electronic)
IS  - 1751-5521 (Linking)
VI  - 31
IP  - 6
DP  - 2009 Dec
TI  - Age-related plasma reference ranges for two heparin-binding proteins--vitronectin 
      and platelet factor 4.
PG  - 683-7
LID - 10.1111/j.1751-553X.2008.01107.x [doi]
AB  - This study was conducted to establish age-related reference ranges for two 
      heparin-binding proteins--vitronectin and platelet factor 4 (PF4)--and to 
      determine if the quantitative values of these proteins may contribute to the 
      reported age-dependent effect of unfractionated heparin (UFH). Plasma samples 
      were obtained from healthy children aged between 1 month and 16 years and from 
      healthy adult volunteers. Two commercial kits were used to measure plasma 
      vitronectin and PF4 levels. Results were reported as mean and boundaries 
      including 95% of the population. Plasma vitronectin levels for children aged 1-5 
      years were significantly higher compared with adults. Plasma PF4 levels for 
      infants <1 year of age were significantly lower compared with adults. The 
      differences between reference values for both proteins in all other age-groups 
      were not statistically significant. This study for the first time has established 
      age-related reference ranges for vitronectin and PF4. In establishing these 
      ranges, the quantitative values of these proteins do not appear to be the major 
      contributory cause for the age-dependent variation in UFH effect. Future studies 
      are required to evaluate the possible impact of age-dependent differences in 
      binding between heparin-binding proteins and UFH.
FAU - Newall, F
AU  - Newall F
AD  - Department of Pathology, The University of Melbourne, Parkville, Melbourne, Vic., 
      Australia. fiona.newall@rch.org.au
FAU - Johnston, L
AU  - Johnston L
FAU - Ignjatovic, V
AU  - Ignjatovic V
FAU - Summerhayes, R
AU  - Summerhayes R
FAU - Monagle, P
AU  - Monagle P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
RN  - 0 (Vitronectin)
RN  - 37270-94-3 (Platelet Factor 4)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Heparin/*metabolism
MH  - Humans
MH  - Infant
MH  - Platelet Factor 4/*blood
MH  - Protein Binding
MH  - Vitronectin/*blood
EDAT- 2009/11/17 06:00
MHDA- 2010/01/16 06:00
CRDT- 2009/11/14 06:00
PHST- 2009/11/14 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/01/16 06:00 [medline]
AID - CLH1107 [pii]
AID - 10.1111/j.1751-553X.2008.01107.x [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2009 Dec;31(6):683-7. doi: 10.1111/j.1751-553X.2008.01107.x.