PMID- 19910894
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20151119
IS  - 0026-4806 (Print)
IS  - 0026-4806 (Linking)
VI  - 100
IP  - 5
DP  - 2009 Oct
TI  - [Homocysteine: a casual link with heart failure?].
PG  - 421-7
AB  - Several studies and recent patents have demonstrated that hyperhomocysteinemia 
      (HHCY) is an independent risk factor for congestive heart failure (CHF); it is 
      also correlated to the severity of the disease. In literature there are some data 
      about effects of HHCY on myocardial structure and function in animal models. 
      These studies indicate a direct effect of HCY in promoting reactive myocardial 
      fibrosis and systolic dysfunction, promoting miocardial redox state, endothelial 
      and mithocondryal dysfunction, negative inotropic effect. According to some 
      authors the HHCY is a potential ethiological factor for heart failure while 
      according to others it is just an epiphenomenon without direct effects on 
      myocardium. Nevertheless the literature studies show the relevant involvement of 
      HHCY in CHF and the strong relations between HHCY plasma levels and the severity 
      and prognosis of the disease. Regarding the potential mechanistic role of HHCY in 
      CHF, all of these studies do not provide any mechanistic insights because of 
      their epidemiological nature. Future studies need to explore the exact 
      pathomechanisms of HHCY in CHF.
FAU - Vizzardi, E
AU  - Vizzardi E
AD  - Department of Cardiology, University of Brescia, Brescia, Italy. 
      enrico.vizzardi@tin.it
FAU - Bonadei, I
AU  - Bonadei I
FAU - Zanini, G
AU  - Zanini G
FAU - Fiorina, C
AU  - Fiorina C
FAU - Raddino, R
AU  - Raddino R
FAU - Dei Cas, L
AU  - Dei Cas L
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Omocisteina e scompenso cardiaco: un'associazione casuale?
PL  - Italy
TA  - Minerva Med
JT  - Minerva medica
JID - 0400732
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Evidence-Based Medicine
MH  - Heart Failure/blood/*etiology/pathology
MH  - Heart Failure, Systolic/metabolism
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*complications
MH  - Myocardium/pathology
MH  - Prognosis
MH  - Risk Factors
MH  - Severity of Illness Index
RF  - 48
EDAT- 2009/11/17 06:00
MHDA- 2010/04/22 06:00
CRDT- 2009/11/14 06:00
PHST- 2009/11/14 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - R10092931 [pii]
PST - ppublish
SO  - Minerva Med. 2009 Oct;100(5):421-7.