PMID- 19910943
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220408
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Feb
TI  - Impact of 6-month caloric restriction on autonomic nervous system activity in 
      healthy, overweight, individuals.
PG  - 414-6
LID - 10.1038/oby.2009.408 [doi]
AB  - Caloric restriction (CR) increases maximum lifespan but the mechanisms are 
      unclear. Dominance of the sympathetic nervous system (SNS) over the 
      parasympathetic nervous system (PNS) has been shown to be a strong risk factor 
      for cardiovascular disease. Obesity and aging are associated with increased SNS 
      activity, and weight loss and/or exercise seem to have positive effects on this 
      balance. We therefore evaluated the effect of different approaches of CR on 
      autonomic function in 28 overweight individuals participating in the 
      Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy 
      (CALERIE) trial. Participants were randomized to either control, CR: 25% decrease 
      in energy intake, CREX: 12.5% CR + 12.5% increase in energy expenditure, or LCD: 
      low-calorie diet until 15% weight reduction followed by weight maintenance. 
      Autonomic function was assessed by spectral analysis of heart-rate variability 
      (HRV) while fasting and after a meal. Measurements were performed at baseline and 
      6 months. HR and SNS index decreased and PNS index increased in all intervention 
      groups but reached significance only in CREX. HR and SNS index increased and PNS 
      index decreased in response to the meal in all intervention groups. The results 
      therefore suggest that weight loss improved SNS/PNS balance especially when CR is 
      combined with exercise.
FAU - de Jonge, Lilian
AU  - de Jonge L
AD  - Pennington Biomedical Research Center, Louisiana State University System, Baton 
      Rouge, Louisiana, USA. dejongeh@pbrc.edu
FAU - Moreira, Emilia A M
AU  - Moreira EA
FAU - Martin, Corby K
AU  - Martin CK
FAU - Ravussin, Eric
AU  - Ravussin E
CN  - Pennington CALERIE Team
LA  - eng
SI  - ClinicalTrials.gov/NCT00099151
GR  - K23 DK068052/DK/NIDDK NIH HHS/United States
GR  - K23 DK068052-01A2/DK/NIDDK NIH HHS/United States
GR  - U01 AG020478/AG/NIA NIH HHS/United States
GR  - U01 AG020478-01/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091112
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
SB  - IM
MH  - Adult
MH  - Autonomic Nervous System/*physiopathology
MH  - *Caloric Restriction
MH  - Combined Modality Therapy
MH  - *Diet, Reducing
MH  - *Energy Metabolism
MH  - *Exercise Therapy
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Overweight/diet therapy/physiopathology/*therapy
MH  - Time Factors
MH  - Treatment Outcome
MH  - Weight Loss
PMC - PMC2882205
MID - NIHMS207675
EDAT- 2009/11/17 06:00
MHDA- 2010/02/23 06:00
PMCR- 2010/06/08
CRDT- 2009/11/14 06:00
PHST- 2009/11/14 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
PHST- 2010/06/08 00:00 [pmc-release]
AID - oby2009408 [pii]
AID - 10.1038/oby.2009.408 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2010 Feb;18(2):414-6. doi: 10.1038/oby.2009.408. Epub 
      2009 Nov 12.