PMID- 19911950
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20181201
IS  - 1097-9867 (Electronic)
IS  - 1083-7450 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Mar-Apr
TI  - Novel buccal adhesive system for anti-hypertensive agent nimodipine.
PG  - 124-30
LID - 10.3109/10837450903055494 [doi]
AB  - Novel buccal adhesive system (NBAS) containing Nimodipine (N) was prepared and 
      evaluated by different parameters such as weight uniformity, thickness, hardness, 
      surface pH, swelling index, mucoadhesive strength (MS), in vitro drug release and 
      ex vivo drug permeation. Different formulations containing 5-20% Carbopol 934 
      (CP) and SCMC HV in sustained release part and sodium alginate:chitosan lactate 
      in different ratios (1:1, 2:1, 1:2, and 3:1) in fast release part were prepared 
      and tested. NBAS containing CP 5% and SCMC HV and sodium alginate: chitosan 
      lactate 1:1 was selected as a suitable formula based on the (MS) and the release 
      profile. Compared to the conventional buccal adhesive tablet, NBAS showed an 
      effective controlled release pattern with faster release at the initial period. 
      The mechanism of N release was found to be by non-fickian diffusion, followed 
      first order release kinetics. It can be considered that NBAS is a superior, novel 
      system that overcomes the drawback associated with the conventional buccal 
      adhesive tablet.
FAU - Hassan, Nisreen
AU  - Hassan N
AD  - Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, 
      New Delhi, India.
FAU - Ali, Mushir
AU  - Ali M
FAU - Ali, Javed
AU  - Ali J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Pharm Dev Technol
JT  - Pharmaceutical development and technology
JID - 9610932
RN  - 0 (Acrylates)
RN  - 0 (Alginates)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Excipients)
RN  - 0 (Hexuronic Acids)
RN  - 0 (Tablets)
RN  - 57WA9QZ5WH (Nimodipine)
RN  - 8A5D83Q4RW (Glucuronic Acid)
RN  - 9012-76-4 (Chitosan)
RN  - K679OBS311 (Carboxymethylcellulose Sodium)
RN  - K6MOM3T5YL (carbopol 934P)
SB  - IM
MH  - Acrylates/chemistry
MH  - Adhesiveness
MH  - Administration, Buccal
MH  - Alginates/chemistry
MH  - Animals
MH  - Antihypertensive Agents/*administration & dosage/chemistry/pharmacokinetics
MH  - Carboxymethylcellulose Sodium/chemistry
MH  - Cattle
MH  - Chitosan/chemistry
MH  - Excipients/*chemistry
MH  - Glucuronic Acid/chemistry
MH  - Hardness
MH  - Hexuronic Acids/chemistry
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Mouth Mucosa/*metabolism
MH  - Nimodipine/*administration & dosage/chemistry/pharmacokinetics
MH  - Permeability
MH  - Surface Properties
MH  - Tablets
EDAT- 2009/11/17 06:00
MHDA- 2010/09/24 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.3109/10837450903055494 [doi]
PST - ppublish
SO  - Pharm Dev Technol. 2010 Mar-Apr;15(2):124-30. doi: 10.3109/10837450903055494.