PMID- 1991267
OWN - NLM
STAT- MEDLINE
DCOM- 19910308
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 67
IP  - 4
DP  - 1991 Feb 15
TI  - Expression of class I and II human leukocyte antigens by thyrocytes and 
      lymphocytic infiltration on human thyroid tumors. An immunofluorescence study.
PG  - 977-83
AB  - Surgical thyroid sections from 30 papillary carcinomas (PC), six medullary 
      carcinomas (MC), three anaplastic carcinomas (AC), two follicular carcinomas 
      (FC), and 16 adenomas (AD) were examined with an indirect immunofluorescence 
      technique employing different monoclonal antibodies to evaluate the expression of 
      human leukocyte antigen (HLA)-A, B, C (Class I) and DR, DP, DQ (Class II) by 
      thyrocytes, together with the phenotype and distribution of inflammatory cells. 
      Ten PC and four FC were also investigated for the presence of intercellular 
      adhesion molecule-1 (ICAM-1). In situ deposits of immunocomplexes and circulating 
      thyroid autoantibodies were also evaluated. An increased expression of Class I 
      antigens was found in all PC and FC, in 33% of MC and AC, and in 31% of AD. An 
      anomalous expression of Class II antigens was observed in 70% of PC, in 50% of 
      FC, in 33% of AC, in 19% of AD, and in none of the MC. Expression of DP or DQ was 
      revealed only in a portion of the DR-positive glands. A reduction of microsomal 
      autoantigen expression was found. No ICAM-1-positive thyrocytes were detected. A 
      moderate T-lymphocytic infiltrate was noticed only in PC, where it was correlated 
      with DR and DP and/or DQ coexpression. B-cells and natural killer cells were 
      virtually absent. The authors speculate that the weak Class II antigens 
      expression, together with the partial or complete loss in microsomal autoantigen 
      and the absence of ICAM-1 by thyrocytes, may account for the limited engagement 
      of immunocompetent cells observed in thyroid tumors.
FAU - Betterle, C
AU  - Betterle C
AD  - Institute of Semeiotica Medica, University of Padua, Italy.
FAU - Presotto, F
AU  - Presotto F
FAU - Caretto, A
AU  - Caretto A
FAU - Pelizzo, M R
AU  - Pelizzo MR
FAU - Pedini, B
AU  - Pedini B
FAU - Girelli, M E
AU  - Girelli ME
FAU - Busnardo, B
AU  - Busnardo B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adenoma/*immunology
MH  - Carcinoma/*immunology
MH  - Carcinoma, Papillary/immunology
MH  - Fluorescent Antibody Technique
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - T-Lymphocyte Subsets/immunology
MH  - Thyroid Neoplasms/*immunology
EDAT- 1991/02/15 00:00
MHDA- 1991/02/15 00:01
CRDT- 1991/02/15 00:00
PHST- 1991/02/15 00:00 [pubmed]
PHST- 1991/02/15 00:01 [medline]
PHST- 1991/02/15 00:00 [entrez]
AID - 10.1002/1097-0142(19910215)67:4<977::aid-cncr2820670420>3.0.co;2-w [doi]
PST - ppublish
SO  - Cancer. 1991 Feb 15;67(4):977-83. doi: 
      10.1002/1097-0142(19910215)67:4<977::aid-cncr2820670420>3.0.co;2-w.