PMID- 19912961
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20091116
IS  - 1044-7431 (Print)
IS  - 1044-7431 (Linking)
VI  - 4
IP  - 6
DP  - 1993 Dec
TI  - On the Neuroendocrine Role of Insulin-like Growth Factors 1 and 2 in the 
      Regulation of Growth Hormone Secretion.
PG  - 538-42
LID - 10.1006/mcne.1993.1066 [doi]
AB  - It has been suggested that insulin-like growth factor-1 (IGF-1) may play a role 
      in the regulation of growth hormone (GH) secretion. However, recent studies using 
      recombinant IGF-1 contradict this. A possible role for IGF-2 has also been 
      postulated, but data for this are fewer. In the present study we have sought to 
      elucidate the role of IGFs in the control of GH secretion by central 
      administration of both IGFs at near physiological doses. Further investigation of 
      their physiological role in GH release has been studied using specific 
      immunoneutralization of IGFs. Sheep with indwelling intracerebroventricular (icv) 
      cannulae were given either IGF-1 (10 mug), IGF-2 (1 or 10 mug), or a combination 
      of IGF-1 and IGF-2 (10 mug of each). Centrally administered IGF-1 had no effect 
      on plasma GH, but IGF-2 caused a sustained decrease (P < 0.01) in plasma GH 
      between 45 and 105 min after injection. The combination of IGF-1 and -2 resulted 
      in a similar decrease in GH levels (P < 0.01). A potent immunoneutralizing 
      antiserum against IGF-1 failed to have any effect on GH levels when administered 
      icv, but administration of antiserum against IGF-2 stimulated GH release (P < 
      0.01) either alone or when administered together with anti-IGF-1 serum. These 
      results indicate that central IGF-1 does not play a role in GH regulation. In 
      contrast, central levels of IGF-2 may be physiologically important in regulating 
      plasma GH levels.
FAU - Spencer, G S
AU  - Spencer GS
AD  - Ruakura Agricultural Centre, Private Bag, Hamilton, New Zealand.
FAU - Berry, C
AU  - Berry C
FAU - Hodgkinson, S C
AU  - Hodgkinson SC
FAU - Bass, J J
AU  - Bass JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
EDAT- 1993/12/01 00:00
MHDA- 1993/12/01 00:01
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 1993/12/01 00:00 [pubmed]
PHST- 1993/12/01 00:01 [medline]
AID - S1044-7431(83)71066-3 [pii]
AID - 10.1006/mcne.1993.1066 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 1993 Dec;4(6):538-42. doi: 10.1006/mcne.1993.1066.