PMID- 19913396
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20211020
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 104
IP  - 3
DP  - 2010 Mar
TI  - Asthma, allergy, and IgE levels in NYC head start children.
PG  - 345-55
LID - 10.1016/j.rmed.2009.10.016 [doi]
AB  - BACKGROUND: Among preschool-age children in New York City neighborhoods with high 
      asthma hospitalization rates, we analyzed the associations of total 
      immunoglobulin E (IgE), specific IgE to common indoor allergens, and allergy 
      symptoms with asthma. METHODS: Parents of children in New York City Head Start 
      programs were asked to complete a questionnaire covering demographic factors, 
      health history (including respiratory conditions), lifestyle, and home 
      environment. Children's serum samples were analyzed for total IgE and specific 
      IgE antibodies to cockroach, dust mite, mouse, and cat allergens by immunoassay. 
      Logistic regression was used to model the association between asthma and IgE, 
      controlling for age, gender, ethnicity/national origin, BMI, parental asthma, 
      smokers in the household, and allergy symptoms (e.g., runny nose, rash). RESULTS: 
      Among 453 participating children (mean age 4.0+/-0.5 years), 150 (33%) met our 
      criteria for asthma. In our multivariable logistic regression models, children 
      with asthma were more likely than other children to be sensitized to each 
      allergen, to be sensitized to any of the four allergens (OR=1.6, 95% CI 1.0-2.6), 
      or to be in the highest quartile of total IgE (OR=3.1, 95% CI 1.5-6.4). Allergy 
      symptoms based on questionnaire responses were independently associated with 
      asthma (OR=3.7, 95% CI 2.3-5.9). CONCLUSIONS: Among preschool-aged urban 
      children, asthma was associated with total IgE and sensitization to cat, mouse, 
      cockroach, and dust mite allergens. However, allergy symptoms were more prevalent 
      and more strongly associated with asthma than was any allergen-specific IgE; such 
      symptoms may precede elevated specific IgE or represent a different pathway to 
      asthma.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Rotsides, Demetra Z
AU  - Rotsides DZ
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      NY 10032, New York, United States.
FAU - Goldstein, Inge F
AU  - Goldstein IF
FAU - Canfield, Stephen M
AU  - Canfield SM
FAU - Perzanowski, Matthew
AU  - Perzanowski M
FAU - Mellins, Robert B
AU  - Mellins RB
FAU - Hoepner, Lori
AU  - Hoepner L
FAU - Ashby-Thompson, Maxine
AU  - Ashby-Thompson M
FAU - Jacobson, Judith S
AU  - Jacobson JS
LA  - eng
GR  - R01 HL068236/HL/NHLBI NIH HHS/United States
GR  - R01 HL068236-01A1/HL/NHLBI NIH HHS/United States
GR  - P30 ES 009/ES/NIEHS NIH HHS/United States
GR  - P30 ES009089/ES/NIEHS NIH HHS/United States
GR  - HL068236/HL/NHLBI NIH HHS/United States
GR  - P30 ES009089-11/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091113
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Allergens)
RN  - 0 (Dust)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Asthma/epidemiology/*immunology
MH  - Cats
MH  - Child, Preschool
MH  - Cockroaches/immunology
MH  - Dose-Response Relationship, Immunologic
MH  - Dust/analysis/immunology
MH  - Early Intervention, Educational
MH  - Female
MH  - Housing
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Mice
MH  - Mites/*immunology
MH  - New York City/epidemiology
MH  - Prevalence
MH  - Skin Tests
MH  - Surveys and Questionnaires
MH  - Urban Health/standards
PMC - PMC2826511
MID - NIHMS154866
EDAT- 2009/11/17 06:00
MHDA- 2010/09/18 06:00
PMCR- 2011/03/01
CRDT- 2009/11/17 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2009/10/16 00:00 [revised]
PHST- 2009/10/20 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - S0954-6111(09)00349-7 [pii]
AID - 10.1016/j.rmed.2009.10.016 [doi]
PST - ppublish
SO  - Respir Med. 2010 Mar;104(3):345-55. doi: 10.1016/j.rmed.2009.10.016. Epub 2009 
      Nov 13.