PMID- 19913587
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20211020
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 2
DP  - 2010 Feb
TI  - Blood soluble human leukocyte antigen G levels are associated with human 
      immunodeficiency virus type 1 infection in Beninese commercial sex workers.
PG  - 182-5
LID - 10.1016/j.humimm.2009.11.007 [doi]
AB  - Human leukocyte antigen (HLA)-G is a powerful modulator of the immune response. 
      The aim of this study was to investigate whether soluble HLA-G (sHLA-G) 
      expression is associated with human immunodeficiency virus type 1 (HIV-1) 
      infection. HIV-1-infected female commercial sex workers (CSWs) had significantly 
      lower levels of plasma sHLA-G compared with those in both the HIV-1-uninfected 
      CSW and the non-CSW groups. The presence of HLA-G*010101, HLA-G*010404 alleles, 
      and the 3'-untranslated region (3'UTR) genetic variant at position 3,952 were all 
      significantly associated with lower plasma sHLA-G levels in the HIV-1-infected 
      CSWs, whereas the HLA-G 3'UTR 14-bp sequence insertion was also associated with 
      lower plasma sHLA-G levels in the overall population. When adjustment was made 
      for all significant variables, the reduced expression of sHLA-G in the plasma 
      remained significantly associated with HIV-1 infection and the HLA-G 3'UTR 14-bp 
      insertion homozygote genotype. This study demonstrates that low levels of plasma 
      sHLA-G are associated with HIV-1 infection.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Lajoie, Julie
AU  - Lajoie J
AD  - Laboratoire d'Immunogenetique, Centre de Recherche du Centre Hospitalier de 
      l'Universite de Montreal, Montreal, Canada.
FAU - Massinga Loembe, Marguerite
AU  - Massinga Loembe M
FAU - Poudrier, Johanne
AU  - Poudrier J
FAU - Guedou, Fernand
AU  - Guedou F
FAU - Pepin, Jacques
AU  - Pepin J
FAU - Labbe, Annie-Claude
AU  - Labbe AC
FAU - Alary, Michel
AU  - Alary M
FAU - Roger, Michel
AU  - Roger M
LA  - eng
GR  - 79213/CAPMC/CIHR/Canada
GR  - HOP-79213/CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091112
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Benin
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HIV Infections/*blood/*genetics/immunology
MH  - HIV-1
MH  - HLA Antigens/*blood/*genetics/immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*blood/*genetics/immunology
MH  - Humans
MH  - Immunoassay
MH  - Sex Work
EDAT- 2009/11/17 06:00
MHDA- 2010/04/08 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/09/15 00:00 [received]
PHST- 2009/11/03 00:00 [revised]
PHST- 2009/11/05 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
AID - S0198-8859(09)00638-7 [pii]
AID - 10.1016/j.humimm.2009.11.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Feb;71(2):182-5. doi: 10.1016/j.humimm.2009.11.007. Epub 2009 
      Nov 12.