PMID- 19913841
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20220409
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 59
IP  - 4
DP  - 2010 Apr
TI  - Gly482Ser polymorphism in the peroxisome proliferator-activated receptor gamma 
      coactivator-1alpha gene is associated with oxidative stress and abdominal 
      obesity.
PG  - 581-6
LID - 10.1016/j.metabol.2009.08.021 [doi]
AB  - The objective of the study was to o investigate the relationship of the Gly482Ser 
      (G482S) polymorphism in the peroxisome proliferator-activated receptor gamma 
      coactivator-1alpha (PPARGC1A) gene and type 2 diabetes mellitus (T2DM), obesity, 
      and oxidative status in Chinese adults. We enrolled 276 T2DM patients and 1049 
      nondiabetic subjects aged at least 35 years. The G482S variant was detected using 
      polymerase chain reaction and restriction enzyme digestion. The levels of 
      thiobarbituric acid reactive substance, an indicator of lipid peroxidation, were 
      measured in plasma samples. The homeostasis model assessment-estimated insulin 
      resistance (HOMA-IR) index was determined for nondiabetic subjects. P values were 
      adjusted for age, sex, and body mass index by using a generalized linear model. 
      In this series, there was no association between G482S polymorphism and T2DM and 
      obesity (body mass index >25 kg/m(2)). However, the plasma fasting insulin levels 
      and HOMA-IR indices were significantly higher in nondiabetic subjects harboring 
      the variant (S/S) genotype than in those with the heterozygous (G/S) genotype. 
      With regard to the effect of the different genotypes on body fat distribution, 
      overweight nondiabetic subjects harboring the S/S or G/S genotype had a 
      significantly higher waist-to-hip ratio than those with the wild-type (G/G) 
      genotype. Furthermore, subjects with the S/S genotype had significantly higher 
      serum thiobarbituric acid reactive substance levels than those with the G/G 
      genotype; the diabetic group mainly contributed to this significant association 
      (P < .001). In overweight, nondiabetic Chinese adults, G482S polymorphism in the 
      PPARGC1A gene is associated with hyperinsulinemia, HOMA-IR indices, and abdominal 
      obesity. Furthermore, in hyperglycemia, the S482 allele is related to increased 
      oxidative stress.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Weng, Shao-Wen
AU  - Weng SW
AD  - Division of Metabolism, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 
      Kaohsiung 83305, Taiwan.
FAU - Lin, Tsu-Kung
AU  - Lin TK
FAU - Wang, Pei-Wen
AU  - Wang PW
FAU - Chen, I-Ya
AU  - Chen IY
FAU - Lee, Hsin-Chen
AU  - Lee HC
FAU - Chen, Shang-Der
AU  - Chen SD
FAU - Chuang, Yao-Chung
AU  - Chuang YC
FAU - Liou, Chia-Wei
AU  - Liou CW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091114
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus/genetics
MH  - Female
MH  - Genotype
MH  - Heat-Shock Proteins/*genetics
MH  - Humans
MH  - Hyperinsulinism/genetics
MH  - Insulin Resistance
MH  - Lipid Peroxidation
MH  - Male
MH  - Middle Aged
MH  - Obesity/genetics/metabolism
MH  - Obesity, Abdominal/*genetics/metabolism
MH  - *Oxidative Stress
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - *Polymorphism, Genetic
MH  - Transcription Factors/*genetics
EDAT- 2009/11/17 06:00
MHDA- 2010/04/08 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/07/09 00:00 [received]
PHST- 2009/08/31 00:00 [revised]
PHST- 2009/08/31 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
AID - S0026-0495(09)00368-0 [pii]
AID - 10.1016/j.metabol.2009.08.021 [doi]
PST - ppublish
SO  - Metabolism. 2010 Apr;59(4):581-6. doi: 10.1016/j.metabol.2009.08.021. Epub 2009 
      Nov 14.