PMID- 19913849
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20220316
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 59
IP  - 6
DP  - 2010 Jun
TI  - Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic 
      syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study-74).
PG  - 774-9
LID - 10.1016/j.metabol.2009.09.022 [doi]
AB  - The aim of the study was to look at the association of angiopoietin-2 (Ang-2) in 
      Asian Indian subjects with different grades of glucose intolerance and in those 
      with hypertension and metabolic syndrome (MS). Three groups were recruited from 
      the Chennai Urban Rural Epidemiology Study, a population-based study in southern 
      India, as follows: group 1, normal glucose tolerance(n = 45); group 2, impaired 
      glucose tolerance (IGT) (n = 45); and group 3, type 2 diabetes mellitus (T2DM) (n 
      = 40). Angiopoietin-2 was estimated by enzyme-linked immunosorbent assay. 
      Hypertension was diagnosed based on medical history, drug treatment of 
      hypertension, and/or if the subjects had systolic blood pressure at least 130 mm 
      Hg and/or diastolic blood pressure at least 85 mm Hg. Metabolic syndrome was 
      defined using modified National Cholesterol Education Program-Adult Treatment 
      Panel III guidelines. Subjects with T2DM had higher age-adjusted Ang-2 values 
      (3741 +/- 1429 pg/mL) compared with subjects with IGT (1907 +/- 855 pg/mL) and 
      normal glucose tolerance (1462 +/- 856 pg/mL) (P for trend < .001). Regression 
      analysis showed that there was a linear increase in mean Ang-2 values with 
      increasing severity of glucose intolerance, even after adjusting for age, sex, 
      and body mass index. Angiopoietin-2 levels were also elevated in subjects with 
      hypertension (P = .004) and in subjects with MS even in the absence of fasting 
      hyperglycemia (P = .011). There was also a linear increase in the mean values of 
      Ang-2 with increase in number of components of MS (P for trend < .001). This 
      study demonstrates that increased levels of Ang-2 are seen in Asian Indian 
      subjects with IGT, T2DM, and hypertension and in subjects with MS even in the 
      absence of fasting hyperglycemia.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Anuradha, Sathish
AU  - Anuradha S
AD  - Madras Diabetes Research Foundation & Dr Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, 
      Gopalapuram, Chennai 600086, India.
FAU - Mohan, Viswanathan
AU  - Mohan V
FAU - Gokulakrishnan, Kuppan
AU  - Gokulakrishnan K
FAU - Dixit, Madhulika
AU  - Dixit M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091114
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Angiopoietin-2)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Angiopoietin-2/*metabolism
MH  - Anthropometry
MH  - Diabetes Mellitus, Type 2/epidemiology/metabolism
MH  - Female
MH  - Glucose Intolerance/epidemiology/*metabolism
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Hypercholesterolemia/blood/epidemiology
MH  - Hypertension/epidemiology/*metabolism
MH  - India/epidemiology
MH  - Male
MH  - Metabolic Syndrome/epidemiology/*metabolism
MH  - Middle Aged
MH  - Regression Analysis
MH  - Risk Factors
MH  - Rural Population
MH  - Urban Population
EDAT- 2009/11/17 06:00
MHDA- 2010/06/12 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/05/20 00:00 [received]
PHST- 2009/09/19 00:00 [revised]
PHST- 2009/09/22 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - S0026-0495(09)00412-0 [pii]
AID - 10.1016/j.metabol.2009.09.022 [doi]
PST - ppublish
SO  - Metabolism. 2010 Jun;59(6):774-9. doi: 10.1016/j.metabol.2009.09.022. Epub 2009 
      Nov 14.