PMID- 19914343
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20181201
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 468
IP  - 3
DP  - 2010 Jan 14
TI  - Myo-inositol treatment prevents biochemical changes triggered by kainate-induced 
      status epilepticus.
PG  - 277-81
LID - 10.1016/j.neulet.2009.11.012 [doi]
AB  - Identification of the compounds preventing the biochemical changes underlying the 
      epileptogenesis process is of great importance. We have previously shown that 
      myo-inositol (MI) administration reduces kainic acid (KA) induced seizure scores. 
      MI treatment effects on biochemical changes triggered by KA induced status 
      epilepticus (SE) were investigated in the present study. After SE one group of 
      rats was treated with saline, whereas the second group with MI. Control groups 
      received either saline or MI administration. Changes in the amounts of following 
      proteins were studied in the hippocampus and neocortex of rats: GLUR1 subunit of 
      glutamate receptors, calcium/calmodulin-dependent protein kinase II (CaMKII), and 
      heat shock protein 90. No changes were found 28-30h after experiments. However on 
      28th day of experiment the amounts of GLUR1 and CaMKII were strongly reduced in 
      the hippocampus of KA treated animals but MI significantly halted this reduction. 
      Obtained results indicate anti-epileptogenic features of MI on biochemical level.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Solomonia, Revaz
AU  - Solomonia R
AD  - Faculty of Life Sciences, I. Chavchavadze State University, Georgia. 
      ros@1000.pvt.ge
FAU - Mikautadze, Ekaterine
AU  - Mikautadze E
FAU - Nozadze, Maia
AU  - Nozadze M
FAU - Kuchiashvili, Nino
AU  - Kuchiashvili N
FAU - Lepsveridze, Eka
AU  - Lepsveridze E
FAU - Kiguradze, Tamar
AU  - Kiguradze T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091113
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Convulsants)
RN  - 0 (HSP90 Heat-Shock Proteins)
RN  - 0 (Receptors, AMPA)
RN  - 4L6452S749 (Inositol)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - SIV03811UC (Kainic Acid)
RN  - TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1)
SB  - IM
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism
MH  - *Convulsants
MH  - HSP90 Heat-Shock Proteins/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Inositol/*pharmacology/therapeutic use
MH  - *Kainic Acid
MH  - Male
MH  - Neocortex/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, AMPA/metabolism
MH  - Status Epilepticus/chemically induced/metabolism/*prevention & control
EDAT- 2009/11/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/09/16 00:00 [received]
PHST- 2009/11/03 00:00 [revised]
PHST- 2009/11/04 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - S0304-3940(09)01478-5 [pii]
AID - 10.1016/j.neulet.2009.11.012 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Jan 14;468(3):277-81. doi: 10.1016/j.neulet.2009.11.012. Epub 
      2009 Nov 13.