PMID- 19915238
OWN - NLM
STAT- MEDLINE
DCOM- 20100205
LR  - 20091116
IS  - 0973-3922 (Electronic)
IS  - 0378-6323 (Linking)
VI  - 75
IP  - 6
DP  - 2009 Nov-Dec
TI  - Comparative case control study of clinical features and human leukocyte antigen 
      susceptibility between familial and nonfamilial vitiligo.
PG  - 583-7
LID - 10.4103/0378-6323.57719 [doi]
AB  - BACKGROUND: Various studies worldwide suggest that human leukocyte antigen (HLA) 
      region may be involved in the genetic susceptibility of vitiligo but little 
      information is available from India. AIM: To find the HLA associated 
      susceptibility to develop vitiligo in Indian patients and to detect role of HLA 
      in familial vitiligo. METHODS: This was a case controlled study which included 
      all patients suffering from vitiligo over a period of one and half years. 
      Clinical details were noted and sera collected from these patients were screened 
      for the presence of HLA class I antibodies. The clinical features and HLA 
      antigens were assessed and comparison was made between patients with familial and 
      nonfamilial vitiligo. RESULTS: Out of 114 patients studied, 84 had family history 
      and 30 had no family history. Patients with family history of vitiligo have 
      higher chances of acquiring vitiligo if first degree relatives are affected 
      compared to if second degree relatives are affected. Family history of vitiligo 
      is associated with an early onset of vitiligo (< 20 years). There was no 
      statistically significant difference in the type, stability, and severity of 
      vitiligo in both the groups. HLA results in both the groups revealed increase in 
      HLA A2, A11, A31, A33, B17, B35, B40, and B44 alleles while HLA A9, B13, and B53 
      alleles were decreased. Family history was associated with HLA A2, A28, A31, and 
      B44 alleles. Early onset of vitiligo (< 20 years) was significantly associated 
      with HLA A2, A11, B17, B35, and B44 alleles. The patients with severe affection 
      (> 10% area) showed in significant association with HLA A10 and B8. CONCLUSION: 
      Family history of vitiligo is associated with an early onset of vitiligo. There 
      is no correlation of family history with the type of vitiligo, stability of 
      lesions, and areas involved. Severity is not associated with family history. 
      Apart from other alleles, alleles A2, and B44 play a significant role in vitiligo 
      in the Indian patients.
FAU - Misri, Rachita
AU  - Misri R
AD  - Department of Dermatology, Seth G S Medical College and KEM Hospital, Parel, 
      Mumbai-400 012, India.
FAU - Khopkar, Uday
AU  - Khopkar U
FAU - Shankarkumar, U
AU  - Shankarkumar U
FAU - Ghosh, K
AU  - Ghosh K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Indian J Dermatol Venereol Leprol
JT  - Indian journal of dermatology, venereology and leprology
JID - 7701852
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Family
MH  - Female
MH  - Genetic Predisposition to Disease/epidemiology
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Vitiligo/*epidemiology/*genetics
MH  - Young Adult
EDAT- 2009/11/17 06:00
MHDA- 2010/02/06 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/02/06 06:00 [medline]
AID - ijdvl_2009_75_6_583_57719 [pii]
AID - 10.4103/0378-6323.57719 [doi]
PST - ppublish
SO  - Indian J Dermatol Venereol Leprol. 2009 Nov-Dec;75(6):583-7. doi: 
      10.4103/0378-6323.57719.