PMID- 19915388
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20220310
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 33
IP  - 6
DP  - 2010 Jun
TI  - Small ubiquitin-like modifier-4 Met55Val polymorphism is associated with glycemic 
      control of Type 2 diabetes mellitus in Taiwan.
PG  - 401-5
AB  - AIM: The development of Type 2 diabetes mellitus (T2DM) has been recognized to be 
      associated with a combination of pancreatic beta-cell dysfunction and insulin 
      resistance. Nuclear factor-kappaB (NF-kappaB) has been recognized as one central 
      mediator in the reaction of inflammation and proapoptotic event in beta-cells. A 
      functional polymorphism at the codon 55 (methionine to valine; A163G) of the 
      small ubiquitin- like modifier-4 (SUMO4) gene may result in higher NF-kappaB 
      activity. This study investigates whether this SUMO4 Met55Val polymorphism also 
      contributes to the development of T2DM. MATERIALS AND METHODS: The study was 
      performed using genomic DNA samples from 574 Type 2 diabetic patients and 323 
      healthy controls. The SUMO4 Met55Val polymorphism was genotyped using 
      allele-specific real-time PCR. RESULTS: The frequency of the G allele (encoding 
      Val55) was significantly higher in Type 2 diabetic patients and Type 2 diabetic 
      patients with the GG genotype had higher hemoglobin A1c level. Multivariate 
      logistic regression analysis revealed the genotype of GG and GA was an 
      independent risk factor contributing to the development of T2DM. CONCLUSION: This 
      study suggests that in Taiwan the SUMO4 Met 55Val polymorphism is associated with 
      susceptibility to T2DM and Type 2 diabetic patients with GG genotype have worse 
      glycemic control.
FAU - Lin, H Y
AU  - Lin HY
AD  - Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Li, S L
AU  - Li SL
FAU - Yu, M L
AU  - Yu ML
FAU - Hsiao, P J
AU  - Hsiao PJ
FAU - Hsieh, M C
AU  - Hsieh MC
FAU - Lin, K D
AU  - Lin KD
FAU - Wang, C L
AU  - Wang CL
FAU - Wang, T N
AU  - Wang TN
FAU - Shin, S J
AU  - Shin SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091112
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Blood Glucose)
RN  - 0 (NF-kappa B)
RN  - 0 (SUMO4 protein, human)
RN  - 0 (Small Ubiquitin-Related Modifier Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B/genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Small Ubiquitin-Related Modifier Proteins/*genetics
MH  - Taiwan
EDAT- 2009/11/17 06:00
MHDA- 2010/10/15 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 6624 [pii]
AID - 10.1007/BF03346611 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2010 Jun;33(6):401-5. doi: 10.1007/BF03346611. Epub 2009 Nov 
      12.