PMID- 19915488
OWN - NLM
STAT- MEDLINE
DCOM- 20091222
LR  - 20220331
IS  - 1554-6578 (Electronic)
IS  - 0022-3069 (Linking)
VI  - 68
IP  - 12
DP  - 2009 Dec
TI  - Effects of 4-methylcatechol on skin reinnervation: promotion of cutaneous nerve 
      regeneration after crush injury.
PG  - 1269-81
LID - 10.1097/NEN.0b013e3181c17b46 [doi]
AB  - We assessed the effects of treatment with 4-methylcatechol (4MC), a known inducer 
      of nerve growth factor, on peripheral nerve regeneration by analyzing cutaneous 
      and muscular reinnervation in mice after sciatic nerve crush injury. At 3 months 
      postinjury, the skin innervation index was significantly higher in the 4MC group 
      than the control group (p=0.0002); there was also increased unmyelinated fiber 
      density (p=0.0042) and unmyelinated fibers/Remak bundle (p = 0.001) in sural 
      nerves, indicating unmyelinated nerve fiber regeneration. These changes were 
      accompanied by increases of transcripts for nerve growth factor (p = 0.0026) and 
      glial cell line-derived neurotrophic factor (p=0.03) in the 4MC group. In 
      contrast, muscle innervation indices were similar in both groups and were higher 
      than the skin innervation index (p < 0.0001). The regeneration of myelinated 
      nerve fibers, as assessed by fiber density, diameter and g ratio analyses in 
      sural nerves, and amplitudes of muscle action potential in sciatic nerves, was 
      similar in both groups. Taken together, these data suggest that 4MC specifically 
      promoted the regeneration of unmyelinated nerve fibers and reinnervation of the 
      skin by increasing the expression of nerve growth factor and glial cell 
      line-derived neurotrophic factor.
FAU - Hsieh, Yu-Lin
AU  - Hsieh YL
AD  - Department of Anatomy and Cell Biology, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Lin, Whei-Min
AU  - Lin WM
FAU - Lue, June-Horng
AU  - Lue JH
FAU - Chang, Ming-Fong
AU  - Chang MF
FAU - Hsieh, Sung-Tsang
AU  - Hsieh ST
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Catechols)
RN  - 0 (Neuroprotective Agents)
RN  - 12GLI7JGB3 (4-methylcatechol)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Catechols/*pharmacology
MH  - Gene Expression/drug effects
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Microscopy, Electron, Transmission
MH  - Muscle, Skeletal/drug effects/*innervation
MH  - Nerve Crush
MH  - Nerve Fibers, Myelinated/drug effects/ultrastructure
MH  - Nerve Fibers, Unmyelinated/drug effects/ultrastructure
MH  - Nerve Growth Factor/biosynthesis/drug effects
MH  - Nerve Regeneration/*drug effects
MH  - Neural Conduction
MH  - Neuromuscular Junction/drug effects/ultrastructure
MH  - Neuroprotective Agents/*pharmacology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sciatic Nerve/injuries
MH  - Skin/drug effects/*innervation
EDAT- 2009/11/17 06:00
MHDA- 2009/12/23 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2009/12/23 06:00 [medline]
AID - 10.1097/NEN.0b013e3181c17b46 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2009 Dec;68(12):1269-81. doi: 
      10.1097/NEN.0b013e3181c17b46.