PMID- 19915493
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20220310
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 50
IP  - 1
DP  - 2010 Jan
TI  - Screening detects a high proportion of celiac disease in young HLA-genotyped 
      children.
PG  - 49-53
LID - 10.1097/MPG.0b013e3181b477a6 [doi]
AB  - BACKGROUND AND AIMS: Celiac disease is associated with tissue transglutaminase 
      autoantibodies (tTGAb) and the human leukocyte antigen (HLA)-risk alleles DQB1*02 
      and DQB1*0302. The aim was to estimate the proportion of undiagnosed celiac 
      disease in children with HLA risk at 3 years of age. PATIENTS AND METHODS: From a 
      population-based HLA-DQ screening study of newborns born between June 2001 and 
      August 2004 in the southern part of Sweden, 6206 children with HLA-risk alleles 
      were identified and asked to participate at a mean 3.3 +/- 0.4 years of age. As 
      controls, 7654 children with HLA-nonrisk alleles were asked to participate. In 
      all, 1620 (26.1%) children with HLA risk and 1815 (23.7%) controls were screened 
      for tTGAb using radioligand-binding assays. Celiac disease was established by 
      intestinal biopsy in children with a confirmed positive tTGAb test. RESULTS: 
      Twenty-three children reported already having clinically diagnosed celiac disease 
      and did not participate further. In children with HLA-risk genotypes, 73 of 1620 
      (4.5%, 95% CI 3.5%-5.5%) were tTGAb-positive compared with none of 1815 from the 
      controls (P < 0.0001). Seventy-one children underwent biopsy (1 refused biopsy 
      and 1 biopsy failed), of whom 56 of 1618 (3.5%, 95% CI 2.6%-4.4%) had damaged 
      intestinal mucosa classified as celiac disease. The ratio between clinically and 
      screening detected celiac disease in this study was 1:2.4 (23:56). CONCLUSIONS: 
      The proportion of clinically undetected celiac disease may be particularly high 
      among 3-year-old children with HLA-DQB1*02 and DQB1*0302 in Sweden, where these 2 
      HLA-risk alleles frequently occur.
FAU - Bjorck, Sara
AU  - Bjorck S
AD  - Unit of Diabetes and Celiac Disease, Department of Clinical Sciences, University 
      Hospital MAS, Lund University, Malmo, Sweden.
FAU - Brundin, Charlotte
AU  - Brundin C
FAU - Lorinc, Ester
AU  - Lorinc E
FAU - Lynch, Kristian F
AU  - Lynch KF
FAU - Agardh, Daniel
AU  - Agardh D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
CIN - J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):242. PMID: 20661080
MH  - Autoantibodies/*genetics/metabolism
MH  - Biopsy
MH  - Celiac Disease/*diagnosis/epidemiology/genetics/immunology
MH  - Child, Preschool
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - *Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Intestinal Mucosa/pathology
MH  - Mass Screening
MH  - Sweden/epidemiology
MH  - Transglutaminases/immunology
EDAT- 2009/11/17 06:00
MHDA- 2010/06/18 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.1097/MPG.0b013e3181b477a6 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2010 Jan;50(1):49-53. doi: 
      10.1097/MPG.0b013e3181b477a6.