PMID- 19917401
OWN - NLM
STAT- MEDLINE
DCOM- 20100224
LR  - 20151119
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 41
IP  - 9
DP  - 2009 Nov
TI  - Relationship between HLA tissue type, CMV infection, and acute graft-vs-host 
      disease after allogeneic hematopoietic stem cell transplantation: single-center 
      experience.
PG  - 3859-62
LID - 10.1016/j.transproceed.2009.04.017 [doi]
AB  - After allogeneic hematopoietic stem cell transplantation, risk factors for 
      cytomegalovirus (CMV) reactivation include pretransplantation donor and recipient 
      CMV serologic status and posttransplantation development of acute graft-vs-host 
      disease (aGvHD). Human leukocyte antigen (HLA) allele type is an additional 
      factor in CMV infection. The present study included 108 patients who received an 
      allogeneic stem cell graft from an HLA-identical sibling between 1993 and 2004. 
      All recipients and donors were typed for HLA-A, HLA-B, and HLA-DR alleles using 
      serologic or molecular methods. All recipients received grafts because of a 
      hematologic disease from HLA full-matched donors. In pretransplantation 
      seropositive patients with aGvHD, no significant difference was observed in 
      patients who developed CMV infection compared with those without CMV infection. 
      Seropositive patients without aGvHD but with posttransplantation CMV infection 
      demonstrated a higher incidence of HLA-A30, HLA-B40, and HLA-DRB1*15 compared 
      with those without CMV infection. In conclusion, it seems that certain HLA 
      alleles may have either a protective or predisposing role in CMV reactivation, 
      which might be helpful in estimating the risk of aGvHD and designing 
      individualized therapy.
FAU - Kekik, C
AU  - Kekik C
AD  - Department of Medical Biology, Istanbul University, Istanbul Medical Faculty, 
      Istanbul, Turkey.
FAU - Besisik, S K
AU  - Besisik SK
FAU - Seyhun, Y
AU  - Seyhun Y
FAU - Oguz, F S
AU  - Oguz FS
FAU - Sargin, D
AU  - Sargin D
FAU - Carin, M N
AU  - Carin MN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Cytomegalovirus Infections/*epidemiology
MH  - Female
MH  - Graft vs Host Disease/*epidemiology/genetics
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - HLA-DR Antigens/immunology
MH  - Hematopoietic Stem Cell Transplantation/adverse effects/*statistics & numerical 
      data
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Precision Medicine/trends
MH  - Retrospective Studies
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2009/11/18 06:00
MHDA- 2010/02/25 06:00
CRDT- 2009/11/18 06:00
PHST- 2008/09/22 00:00 [received]
PHST- 2009/02/13 00:00 [revised]
PHST- 2009/04/13 00:00 [accepted]
PHST- 2009/11/18 06:00 [entrez]
PHST- 2009/11/18 06:00 [pubmed]
PHST- 2010/02/25 06:00 [medline]
AID - S0041-1345(09)01446-8 [pii]
AID - 10.1016/j.transproceed.2009.04.017 [doi]
PST - ppublish
SO  - Transplant Proc. 2009 Nov;41(9):3859-62. doi: 10.1016/j.transproceed.2009.04.017.