PMID- 19917421
OWN - NLM
STAT- MEDLINE
DCOM- 20100224
LR  - 20200924
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 41
IP  - 9
DP  - 2009 Nov
TI  - Acute graft-versus-host-disease in kidney transplantation: case report and review 
      of literature.
PG  - 3949-52
LID - 10.1016/j.transproceed.2009.05.030 [doi]
AB  - Graft-versus-host-disease (GVHD) is a complication of solid organ 
      transplantation, most commonly of the small bowel or liver. Herein, we have 
      presented a case of GVHD in a 27-year-old man who underwent an human leukocyte 
      antigen (HLA) minor mismatch renal transplantation from his father. After the 
      procedure, the patient presented with a fever, skin rash, and watery diarrhea. An 
      allograft kidney biopsy demonstrated no sign of rejection; however, anti-A 
      antibody was detected in plasma and progressive anemia was attributed to 
      hemolytic anemia owing to a passenger lymphocyte syndrome. From those findings, 
      we suspected that the clinical symptoms were caused by acute GVHD. An endoscopic 
      biopsy of the colon revealed apoptotic cells consistent with the disease. We 
      found reports of only 5 other GVHD cases after kidney transplantation. Several 
      risk factors are associated with GVHD, such as transfer of graft lymphocytes, 
      donor HLA homozygosity, and a relationship between recipient immunogenicity and 
      immunosuppression. In this case, detection led to early diagnosis of 
      donor-derived GVHD due to passenger lymphocyte syndrome. It is important keep 
      GVHD in mind and to understand its risk factors as the mortality rate is high.
FAU - Kato, Taigo
AU  - Kato T
AD  - Department of Urology, Osaka General Medical Center, Osaka, Japan. 
      taigo_kato@yahoo.co.jp
FAU - Yazawa, Koji
AU  - Yazawa K
FAU - Madono, Keigo
AU  - Madono K
FAU - Saito, Jun
AU  - Saito J
FAU - Hosomi, Masahiro
AU  - Hosomi M
FAU - Itoh, Kiichiro
AU  - Itoh K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 5GMR90S4KN (Methylprednisolone Hemisuccinate)
RN  - HU9DX48N0T (Mycophenolic Acid)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Anemia, Hemolytic/diagnosis
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Bacterial Infections/diagnosis/drug therapy
MH  - Female
MH  - Graft vs Host Disease/*drug therapy
MH  - HLA Antigens/analysis
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Kidney Transplantation/*adverse effects/immunology
MH  - Male
MH  - Methylprednisolone Hemisuccinate/therapeutic use
MH  - Mycophenolic Acid/analogs & derivatives/therapeutic use
MH  - Pancreas Transplantation/adverse effects
MH  - Reoperation
MH  - Treatment Outcome
EDAT- 2009/11/18 06:00
MHDA- 2010/02/25 06:00
CRDT- 2009/11/18 06:00
PHST- 2009/03/20 00:00 [received]
PHST- 2009/05/04 00:00 [accepted]
PHST- 2009/11/18 06:00 [entrez]
PHST- 2009/11/18 06:00 [pubmed]
PHST- 2010/02/25 06:00 [medline]
AID - S0041-1345(09)01346-3 [pii]
AID - 10.1016/j.transproceed.2009.05.030 [doi]
PST - ppublish
SO  - Transplant Proc. 2009 Nov;41(9):3949-52. doi: 10.1016/j.transproceed.2009.05.030.