PMID- 19919645
OWN - NLM
STAT- MEDLINE
DCOM- 20100310
LR  - 20100629
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 121
IP  - 1
DP  - 2010 Jan
TI  - Multiple sclerosis in a family on the Faroe Islands.
PG  - 16-9
LID - 10.1111/j.1600-0404.2009.01291.x [doi]
AB  - BACKGROUND: John Kurtzke has proposed that multiple sclerosis (MS) on the Faroe 
      Islands occurred as a result of the spread of a transmittable agent brought to 
      the country during World War II. AIM: Kurtzke's theory has been opposed earlier 
      and in this study, we present a family from the Faroe Islands containing a total 
      of 14 family members with MS which show further inconsistencies with the theory. 
      The present study is to our knowledge, the first description of familial 
      incidences of MS on the Faroe Islands. METHODS: Medical histories were gathered 
      from 12 family members and 6 of the 8 living MS cases were human leukocyte 
      antigen (HLA)-typed. RESULTS: Seven family members had primary progressive MS 
      (PPMS), while five had relapsing remitting MS. The HLA-DR15 allele was carried by 
      the three cases with the most aggressive form of MS and they shared a common 
      haplotypes. The HLA types carried by the remaining cases varied. CONCLUSION: This 
      research questions Kurtzke's theory as three of the cases do not conform to the 
      epidemic cohorts described. Furthermore, there appears to be a higher than usual 
      prevalence of PPMS. The high degree of heterogeneity of the HLA types carried 
      indicates that HLA alleles do not independently explain the risk of developing 
      MS.
FAU - Binzer, S
AU  - Binzer S
AD  - Brighton and Sussex Medical School, Brighton, United Kingdom. 
      s.b.binzer@bsms.ac.uk
FAU - Imrell, K
AU  - Imrell K
FAU - Binzer, M
AU  - Binzer M
FAU - Vang, S
AU  - Vang S
FAU - Rogvi-Hansen, B
AU  - Rogvi-Hansen B
FAU - Hillert, J
AU  - Hillert J
FAU - Stenager, E
AU  - Stenager E
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091116
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Acta Neurol Scand. 2010 Jun;121(6):429-31; author reply 432. PMID: 20578998
MH  - Adult
MH  - Denmark/epidemiology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*epidemiology/*genetics
MH  - Pedigree
MH  - Prevalence
MH  - Young Adult
EDAT- 2009/11/19 06:00
MHDA- 2010/03/11 06:00
CRDT- 2009/11/19 06:00
PHST- 2009/11/19 06:00 [entrez]
PHST- 2009/11/19 06:00 [pubmed]
PHST- 2010/03/11 06:00 [medline]
AID - ANE1291 [pii]
AID - 10.1111/j.1600-0404.2009.01291.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2010 Jan;121(1):16-9. doi: 10.1111/j.1600-0404.2009.01291.x. 
      Epub 2009 Nov 16.