PMID- 19919716
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20091216
LR  - 20220311
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 2
DP  - 2009 Nov 17
TI  - Importance of xenarthrans in the eco-epidemiology of Paracoccidioides 
      brasiliensis.
PG  - 228
LID - 10.1186/1756-0500-2-228 [doi]
AB  - BACKGROUND: Several pathogens that cause important zoonotic diseases have been 
      frequently associated with armadillos and other xenarthrans. This mammal group 
      typically has evolved on the South American continent and many of its extant 
      species are seriously threatened with extinction. Natural infection of armadillos 
      with Paracoccidioides brasiliensis in hyperendemic areas has provided a valuable 
      opportunity for understanding the role of this mammal in the eco-epidemiology of 
      Paracoccidioidomycosis (PCM), one of the most important systemic mycoses in Latin 
      America. FINDINGS: This study aimed to detect P. brasiliensis in different 
      xenarthran species (Dasypus novemcinctus, Cabassous spp., Euphractus sexcinctus, 
      Tamandua tetradactyla and Myrmecophaga tridactyla), by molecular and mycological 
      approaches, in samples obtained by one of the following strategies: i) from 
      road-killed animals (n = 6); ii) from naturally dead animals (n = 8); iii) from 
      animals that died in captivity (n = 9); and iv) from living animals captured from 
      the wild (n = 2). Specific P. brasiliensis DNA was detected in several organs 
      among 7/20 nine-banded armadillos (D. novemcinctus) and in 2/2 anteaters (M. 
      tridactyla). The fungus was also cultured in tissue samples from one of two 
      armadillos captured from the wild. CONCLUSION: Members of the Xenarthra Order, 
      especially armadillos, have some characteristics, including a weak cellular 
      immune response and low body temperature, which make them suitable models for 
      studying host-pathogen interaction. P. brasiliensis infection in wild animals, 
      from PCM endemic areas, may be more common than initially postulated and 
      reinforces the use of these animals as sentinels for the pathogen in the 
      environment.
FAU - Richini-Pereira, Virginia B
AU  - Richini-Pereira VB
AD  - Departamento de Microbiologia e Imunologia, Instituto de Biociencias de Botucatu, 
      Universidade Estadual Paulista, Botucatu, SP, Brasil. virichini@yahoo.com.br
FAU - Bosco, Sandra M G
AU  - Bosco SM
FAU - Theodoro, Raquel C
AU  - Theodoro RC
FAU - Barrozo, Ligia
AU  - Barrozo L
FAU - Pedrini, Silvia C B
AU  - Pedrini SC
FAU - Rosa, Patricia S
AU  - Rosa PS
FAU - Bagagli, Eduardo
AU  - Bagagli E
LA  - eng
PT  - Journal Article
DEP - 20091117
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
PMC - PMC2784786
EDAT- 2009/11/19 06:00
MHDA- 2009/11/19 06:01
PMCR- 2009/11/17
CRDT- 2009/11/19 06:00
PHST- 2009/05/19 00:00 [received]
PHST- 2009/11/17 00:00 [accepted]
PHST- 2009/11/19 06:00 [entrez]
PHST- 2009/11/19 06:00 [pubmed]
PHST- 2009/11/19 06:01 [medline]
PHST- 2009/11/17 00:00 [pmc-release]
AID - 1756-0500-2-228 [pii]
AID - 10.1186/1756-0500-2-228 [doi]
PST - epublish
SO  - BMC Res Notes. 2009 Nov 17;2:228. doi: 10.1186/1756-0500-2-228.