PMID- 19923020
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110222
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 147
IP  - 2
DP  - 2011 Mar 3
TI  - Reduction and activation of circulating dendritic cells in patients with 
      decompensated heart failure.
PG  - 258-64
LID - 10.1016/j.ijcard.2009.09.524 [doi]
AB  - BACKGROUND: Dendritic cells (DCs) are the most potent antigen-presenting cells 
      and play a central role in initiating the primary immune response. Although 
      increasing evidence supports immune-mediated inflammation plays an important role 
      in the pathophysiology of heart failure, little is known regarding the source and 
      mechanism that trigger immune responses. The present study examined whether 
      circulating DCs have any role in the pathophysiology in heart failure in humans. 
      METHODS AND RESULTS: With multi-color flow cytometry we determined the numbers of 
      circulating myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in decompensated heart 
      failure patients with NYHA class III or IV on admission (n = 27) and the 
      age-similar control subjects (n = 21). DC activation markers such as CD40, and 
      CCR7 were also measured. On admission, circulating mDC and pDC counts were 
      significantly lower in decompensated heart failure patients compared to control 
      subjects (p < 0.01). Circulating mDCs and pDCs were activated in the 
      decompensated heart failure patients. Heart failure treatment restored the 
      reduction and the activation of circulating mDCs and pDCs (p < 0.05). The 
      increases of circulating DCs numbers after treatment were correlated with the 
      decreases in B-type natriuretic peptide (BNP) and troponin-T (p < 0.05) and with 
      the increase in left ventricular ejection fraction (LVEF) (p < 0.01). 
      Furthermore, we found that poor recovery of the circulating DCs number after 
      treatment predicted recurrence of decompensated heart failure. CONCLUSION: These 
      findings suggest that the reduction and activation of circulating DCs may be 
      involved in the pathophysiology of heart failure.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Sugi, Yusuke
AU  - Sugi Y
AD  - Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume 
      University, 67 Asahi-machi, Kurume 830-0011, Japan.
FAU - Yasukawa, Hideo
AU  - Yasukawa H
FAU - Kai, Hisashi
AU  - Kai H
FAU - Fukui, Daisuke
AU  - Fukui D
FAU - Futamata, Nobuyoshi
AU  - Futamata N
FAU - Mawatari, Kazuhisa
AU  - Mawatari K
FAU - Oba, Toyoharu
AU  - Oba T
FAU - Nagata, Nobutaka
AU  - Nagata N
FAU - Kyougoku, Sachiko
AU  - Kyougoku S
FAU - Koga, Mitsuhisa
AU  - Koga M
FAU - Imaizumi, Tsutomu
AU  - Imaizumi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091117
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Aged
MH  - Cell Count
MH  - Dendritic Cells/*cytology/*immunology
MH  - Female
MH  - Flow Cytometry/methods
MH  - Fluorescent Antibody Technique
MH  - Heart Failure/*immunology/*pathology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
EDAT- 2009/11/20 06:00
MHDA- 2011/06/22 06:00
CRDT- 2009/11/20 06:00
PHST- 2009/01/18 00:00 [received]
PHST- 2009/09/15 00:00 [revised]
PHST- 2009/09/25 00:00 [accepted]
PHST- 2009/11/20 06:00 [entrez]
PHST- 2009/11/20 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - S0167-5273(09)01466-1 [pii]
AID - 10.1016/j.ijcard.2009.09.524 [doi]
PST - ppublish
SO  - Int J Cardiol. 2011 Mar 3;147(2):258-64. doi: 10.1016/j.ijcard.2009.09.524. Epub 
      2009 Nov 17.