PMID- 19925795
OWN - NLM
STAT- MEDLINE
DCOM- 20091231
LR  - 20211020
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 584
IP  - 2
DP  - 2010 Jan 21
TI  - tRNA as an active chemical scaffold for diverse chemical transformations.
PG  - 366-75
LID - 10.1016/j.febslet.2009.11.045 [doi]
AB  - During protein synthesis, tRNA serves as the intermediary between cognate amino 
      acids and their corresponding RNA trinucleotide codons. Aminoacyl-tRNA is also a 
      biosynthetic precursor and amino acid donor for other macromolecules. AA-tRNAs 
      allow transformations of acidic amino acids into their amide-containing 
      counterparts, and seryl-tRNA(Ser) donates serine for antibiotic synthesis. 
      Aminoacyl-tRNA is also used to cross-link peptidoglycan, to lysinylate the lipid 
      bilayer, and to allow proteolytic turnover via the N-end rule. These alternative 
      functions may signal the use of RNA in early evolution as both a biological 
      scaffold and a catalyst to achieve a wide variety of chemical transformations.
FAU - Francklyn, Christopher S
AU  - Francklyn CS
AD  - Cell and Molecular Biology Program, University of Vermont, Burlington, VT 05405, 
      United States. Christopher.Francklyn@uvm.edu
FAU - Minajigi, Anand
AU  - Minajigi A
LA  - eng
GR  - R01 GM054899/GM/NIGMS NIH HHS/United States
GR  - R01 GM054899-13/GM/NIGMS NIH HHS/United States
GR  - GM54899/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Membrane Lipids)
RN  - 0 (Peptidoglycan)
RN  - 0 (Proteins)
RN  - 0 (RNA, Transfer, Amino Acyl)
RN  - 0 (Tetrapyrroles)
SB  - IM
MH  - Anti-Bacterial Agents/biosynthesis
MH  - Bacteria/*metabolism
MH  - Membrane Lipids/metabolism
MH  - Peptidoglycan/biosynthesis
MH  - Protein Biosynthesis
MH  - Proteins/metabolism
MH  - RNA, Transfer, Amino Acyl/biosynthesis/*chemistry/*metabolism
MH  - Tetrapyrroles/biosynthesis
PMC - PMC3241936
MID - NIHMS159867
COIS- Conflict of interest: Authors declare no conflict of interest
EDAT- 2009/11/21 06:00
MHDA- 2010/01/01 06:00
PMCR- 2011/12/17
CRDT- 2009/11/21 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2009/11/11 00:00 [revised]
PHST- 2009/11/11 00:00 [accepted]
PHST- 2009/11/21 06:00 [entrez]
PHST- 2009/11/21 06:00 [pubmed]
PHST- 2010/01/01 06:00 [medline]
PHST- 2011/12/17 00:00 [pmc-release]
AID - S0014-5793(09)00958-2 [pii]
AID - 10.1016/j.febslet.2009.11.045 [doi]
PST - ppublish
SO  - FEBS Lett. 2010 Jan 21;584(2):366-75. doi: 10.1016/j.febslet.2009.11.045.