PMID- 19926678
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20211028
IS  - 1521-0081 (Electronic)
IS  - 0031-6997 (Print)
IS  - 0031-6997 (Linking)
VI  - 61
IP  - 4
DP  - 2009 Dec
TI  - Metabotropic glutamate receptor-mediated long-term depression: molecular 
      mechanisms.
PG  - 395-412
LID - 10.1124/pr.109.001735 [doi]
AB  - The ability to modify synaptic transmission between neurons is a fundamental 
      process of the nervous system that is involved in development, learning, and 
      disease. Thus, synaptic plasticity is the ability to bidirectionally modify 
      transmission, where long-term potentiation and long-term depression (LTD) 
      represent the best characterized forms of plasticity. In the hippocampus, two 
      main forms of LTD coexist that are mediated by activation of either 
      N-methyl-d-aspartic acid receptors (NMDARs) or metabotropic glutamate receptors 
      (mGluRs). Compared with NMDAR-LTD, mGluR-LTD is less well understood, but recent 
      advances have started to delineate the underlying mechanisms. mGluR-LTD at 
      CA3:CA1 synapses in the hippocampus can be induced either by synaptic stimulation 
      or by bath application of the group I selective agonist 
      (R,S)-3,5-dihydroxyphenylglycine. Multiple signaling mechanisms have been 
      implicated in mGluR-LTD, illustrating the complexity of this form of plasticity. 
      This review provides an overview of recent studies investigating the molecular 
      mechanisms underlying hippocampal mGluR-LTD. It highlights the role of key 
      molecular components and signaling pathways that are involved in the induction 
      and expression of mGluR-LTD and considers how the different signaling pathways 
      may work together to elicit a persistent reduction in synaptic transmission.
FAU - Gladding, Clare M
AU  - Gladding CM
AD  - MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, 
      School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK.
FAU - Fitzjohn, Stephen M
AU  - Fitzjohn SM
FAU - Molnar, Elek
AU  - Molnar E
LA  - eng
GR  - G0601509/MRC_/Medical Research Council/United Kingdom
GR  - 57294/MRC_/Medical Research Council/United Kingdom
GR  - BB/F011326/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - 80049/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091119
PL  - United States
TA  - Pharmacol Rev
JT  - Pharmacological reviews
JID - 0421737
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Receptors, Metabotropic Glutamate)
SB  - IM
MH  - Animals
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Humans
MH  - Long-Term Synaptic Depression/drug effects/*physiology
MH  - Neurons/drug effects/metabolism
MH  - Receptors, Metabotropic Glutamate/genetics/metabolism/*physiology
PMC - PMC2802426
EDAT- 2009/11/21 06:00
MHDA- 2010/03/05 06:00
PMCR- 2010/06/01
CRDT- 2009/11/21 06:00
PHST- 2009/11/21 06:00 [entrez]
PHST- 2009/11/21 06:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - pr.109.001735 [pii]
AID - 3549162 [pii]
AID - 10.1124/pr.109.001735 [doi]
PST - ppublish
SO  - Pharmacol Rev. 2009 Dec;61(4):395-412. doi: 10.1124/pr.109.001735. Epub 2009 Nov 
      19.