PMID- 19927626
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20161125
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 37
IP  - 6
DP  - 2009 Jun
TI  - [Association of plasma amino-terminal pro-A-, B- and C-type natriuretic peptide 
      levels with NYHA grade and echocardiographic derived parameters of cardiac 
      function in heart failure patients].
PG  - 486-90
AB  - OBJECTIVE: To observe the correlation of plasma amino-terminal pro-A-, B- and 
      C-type natriuretic peptide (NT-proANP, NT-proBNP and NT-proCNP) levels with New 
      York Heart Association (NYHA) functional class and echocardiographic derived 
      parameters of cardiac function in heart failure patients. METHODS: Data of NYHA 
      grade, echocardiographic derived parameters of cardiac function, plasma levels of 
      NT-proANP, NT-proBNP and NT-proCNP (measured by enzyme immunoassay method) were 
      obtained in 112 heart failure patients and 44 normal control subjects. The 
      correlation analysis was made between NT-proANP, NT-proBNP, NT-proCNP and NYHA 
      functional class, left atrium diameter (LAD), left ventricular end-diastolic 
      diameter (LVEDD) and left ventricular ejection fraction (LVEF), respectively. 
      RESULTS: The plasma concentrations of NT-proANP, NT-proBNP and NT-proCNP in heart 
      failure patients were significantly higher than in control group (all P<0.05). 
      Correlation analysis revealed a strong correlation between NT-proANP and 
      NT-proBNP (r = 0.790, P = 0.000) and a weak correlation between NT-proCNP and 
      NT-proBNP (r = 0.278, P = 0.003) as well as between NT-proCNP and NT-proANP (r = 
      0.236, P = 0.012) in heart failure patients. Univariant analysis showed that 
      NT-proANP and NT-proBNP were positively correlated to LAD, LVEDD and negatively 
      correlated to LVEF (all P<0.05) while there was no significant correlation 
      between NT-proCNP and echocardiographic derived parameters of cardiac function in 
      heart failure patients. Multivariate stepwise regression analysis including age, 
      gender, NYHA classification, LAD, LVEDD and LVEF revealed that NYHA 
      classification, LVEF, LAD and age were independent predictors of NT-proANP; while 
      NYHA classification, LVEF and age were independent predictors of NT-proBNP while 
      there was no association among these factors and NT-proCNP. CONCLUSION: In heart 
      failure patients, the plasma concentration of NT-proANP, NT-proBNP and NT-proCNP 
      were significantly increased and NT-proANP, NT-proBNP but not NT-proCNP were 
      significantly correlated to NYHA classification and echocardiographic derived 
      parameters of cardiac function.
FAU - Zhao, Xue-yan
AU  - Zhao XY
AD  - Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, 
      China.
FAU - Yang, Yue-jin
AU  - Yang YJ
FAU - Zhang, Jian
AU  - Zhang J
FAU - Kang, Lian-ming
AU  - Kang LM
FAU - Wei, Bing-qi
AU  - Wei BQ
FAU - Gao, Xiao-jin
AU  - Gao XJ
FAU - Lu, Rong
AU  - Lu R
FAU - Zhang, Chun-ling
AU  - Zhang CL
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 127869-51-6 (Natriuretic Peptide, C-Type)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atrial Natriuretic Factor/blood
MH  - Case-Control Studies
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/*blood/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Natriuretic Peptide, C-Type/blood
MH  - Ventricular Function, Left
EDAT- 2009/11/26 06:00
MHDA- 2010/05/12 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Jun;37(6):486-90.