PMID- 19927696
OWN - NLM
STAT- MEDLINE
DCOM- 20091215
LR  - 20200423
IS  - 1050-0545 (Print)
IS  - 1050-0545 (Linking)
VI  - 20
IP  - 4
DP  - 2009 Apr
TI  - The time course of the amplitude and latency in the auditory late response evoked 
      by repeated tone bursts.
PG  - 239-50
AB  - BACKGROUND: This study provides a detailed description of the time course of 
      amplitude and latency in the auditory late response (ALR) elicited by repeated 
      tone bursts. RESEARCH DESIGN: Tone bursts (50 and 80 dB SPL) were presented via 
      insert earphones in trains of ten with interstimulus intervals (ISIs) of 0.7 and 
      2 msec and an intertrain interval of 15 sec. Averages were derived independently 
      for each tone burst within the train across the total number of train 
      presentations. STUDY SAMPLE: Participants were 14 normal-hearing young adults. 
      DATA COLLECTION AND ANALYSIS: Data were analyzed in terms of the amplitudes and 
      latencies of the N1 and P2 waves of the ALR as well as the N1-P2 amplitude. 
      RESULTS: The N1-P2 amplitude was a more stable measure than the amplitude of 
      individual N1 and P2 peaks. The N1-P2 amplitude was maximal for the first tone 
      burst and decreased in a nonmonotonic pattern for the remainder of the tone 
      bursts within a stimulus train. The amplitude decrement was dependent on stimulus 
      intensity and ISI. The latencies of N1 and P2 were maximal for the first tone 
      burst and reduced approximately 20% for the rest of the stimuli in a train. The 
      time course of N1 and P2 latencies was not dependent on stimulus intensity and 
      ISI. CONCLUSIONS: The reduction of latency in the time course of the ALR might be 
      related to the fact that neurons with shorter latencies had faster recovery speed 
      from adaptation and/or refractoriness than those with longer latencies. This 
      finding is meaningful in the context of future research to restore normal 
      adaptation in abnormal hearing populations such as cochlear implant patients.
FAU - Zhang, Fawen
AU  - Zhang F
AD  - Department of Communication Sciences and Disorders, University of Cincinnati, OH, 
      USA. Fawen.Zhang@uc.edu
FAU - Eliassen, James
AU  - Eliassen J
FAU - Anderson, Jill
AU  - Anderson J
FAU - Scheifele, Peter
AU  - Scheifele P
FAU - Brown, David
AU  - Brown D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Acad Audiol
JT  - Journal of the American Academy of Audiology
JID - 9114646
SB  - IM
MH  - *Acoustic Stimulation
MH  - Adaptation, Physiological
MH  - Adult
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Reaction Time/*physiology
MH  - Refractory Period, Electrophysiological
MH  - Young Adult
EDAT- 2009/11/26 06:00
MHDA- 2009/12/16 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.3766/jaaa.20.4.4 [doi]
PST - ppublish
SO  - J Am Acad Audiol. 2009 Apr;20(4):239-50. doi: 10.3766/jaaa.20.4.4.