PMID- 19929927
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20221207
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Feb
TI  - Prevalence, human leukocyte antigen typing and strategy for screening among Asian 
      first-degree relatives of children with celiac disease.
PG  - 319-24
LID - 10.1111/j.1440-1746.2009.06044.x [doi]
AB  - BACKGROUND AND AIM: Data on prevalence, human leukocyte antigen (HLA) typing and 
      small bowel histology among first-degree relatives of subjects with celiac 
      disease (CD) is scarce. This prospective study evaluated the prevalence and role 
      of HLA DQ2/8 testing in screening of first-degree relatives of children with CD. 
      METHODS: Thirty confirmed children with CD and 91/94 first-degree relatives 
      (parents and siblings) were enrolled. HLA DQ2/8 testing was carried out in all 
      index CD cases. Clinical evaluation with a questionnaire, total serum 
      immunoglobulin A (IgA), human IgA-tissue transglutaminase (IgA-tTGA) and HLA 
      DQ2/8 testing was carried out in all first-degree relatives. Subjects who were 
      positive for IgA-tTGA were recommended endoscopic duodenal biopsy to document 
      histological changes of CD. RESULTS: Nine first-degree relatives were positive 
      for IgA-tTGA, seven underwent duodenal biopsy and four subjects had Marsh IIIa 
      changes suggestive of CD. The prevalence of histologically confirmed CD in 
      first-degree relatives was 4.4%. The prevalence of potential CD was 9.8%. 
      IgA-tTGA-positive subjects (4/9) were significantly more often symptomatic than 
      IgA-tTGA-negative first-degree relatives (2/82). Twenty-nine (96.6%) index cases 
      of CD and all IgA-tTGA-positive first-degree relatives were positive for HLA DQ2. 
      None of the index CD cases or first-degree relatives were HLA DQ8-positive. A 
      total of 85% of the first-degree relatives were positive for HLA DQ2 and thus at 
      risk of developing CD. CONCLUSIONS: In this first Asian study on a limited number 
      of families of children with CD, 4.4% of the first-degree relatives had CD. Only 
      15% of the first-degree relatives were negative for HLA DQ2/DQ8. Initial 
      evaluation with HLA and serology followed by only serial serology in HLA-positive 
      relatives is recommended.
FAU - Srivastava, Anshu
AU  - Srivastava A
AD  - Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of 
      Medical Sciences, Lucknow, India.
FAU - Yachha, Surender Kumar
AU  - Yachha SK
FAU - Mathias, Amrita
AU  - Mathias A
FAU - Parveen, Farah
AU  - Parveen F
FAU - Poddar, Ujjal
AU  - Poddar U
FAU - Agrawal, Suraksha
AU  - Agrawal S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091119
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - EC 2.3.2.13 (Transglutaminases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People/*genetics
MH  - Autoantibodies/blood
MH  - Biopsy
MH  - Celiac Disease/*diagnosis/ethnology/genetics/immunology/pathology
MH  - Child
MH  - Child, Preschool
MH  - Duodenoscopy
MH  - Female
MH  - HLA-DQ Antigens/*blood
MH  - *Histocompatibility Testing
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - Pedigree
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Transglutaminases/immunology
EDAT- 2009/11/26 06:00
MHDA- 2010/04/24 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - JGH6044 [pii]
AID - 10.1111/j.1440-1746.2009.06044.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2010 Feb;25(2):319-24. doi: 
      10.1111/j.1440-1746.2009.06044.x. Epub 2009 Nov 19.