PMID- 19931033
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20100805
IS  - 1873-4022 (Electronic)
IS  - 1873-4022 (Linking)
VI  - 35
IP  - 3
DP  - 2010 Autumn
TI  - Helical tomotherapy and larynx sparing in advanced oropharyngeal carcinoma: a 
      dosimetric study.
PG  - 214-9
LID - 10.1016/j.meddos.2009.06.002 [doi]
AB  - Intensity-modulated radiation therapy (IMRT) is gaining acceptance as a standard 
      treatment technique for advanced squamous cell carcinoma (SCC) of the oropharynx. 
      Dose to the uninvolved larynx and surrounding structures can pose a problem in 
      patients with significant neck disease, potentially compromising laryngeal 
      function and quality of life. Tomotherapy may allow greater laryngeal sparing. 
      Seven patients with stage IV SCC of the oropharynx were replanned using 
      Tomotherapy version 3.1. All contours/planning target volumes (PTVs) from the 
      original plans were preserved, with the exception of the larynx, which was drawn 
      to include all soft tissue encompassed by the thyroid/cricoid cartilage. A 
      simultaneous integrated boost technique was used with PTV 1, 2, and 3 receiving 
      69.96, 59.40, and 54.00 Gy, respectively in 33 fractions. Dosimetry was evaluated 
      via the Pinnacle treatment planning system (TPS). Equivalent uniform dose (EUD) 
      was calculated from the dose volume histogram (DVH) using the general method with 
      "a" = 5.0. Mean larynx dose for all patients was 24.4 Gy. Mean EUD to the larynx 
      was 34.2 Gy. Homogeneity was adequate; average maximum dose was 109.7% of the 
      highest prescription. All other organs at risk (OAR) were adequately spared. 
      Tomotherapy can spare the uninvolved larynx in the setting of advanced SCC of the 
      oropharynx to levels that are similar to or better than those reported with other 
      techniques. Sparing is achieved without compromising target coverage or other OAR 
      sparing. The clinical benefit of this sparing remains to be determined in a 
      prospective study.
CI  - 2010 American Association of Medical Dosimetrists. Published by Elsevier Inc. All 
      rights reserved.
FAU - Gielda, Benjamin T
AU  - Gielda BT
AD  - Department of Radiation Oncology, Rush University Medical Center Chicago, IL 
      60612, USA. benjamin_gielda@rush.edu
FAU - Millunchick, Cheryl H
AU  - Millunchick CH
FAU - Smart, Joseph P
AU  - Smart JP
FAU - Marsh, James C
AU  - Marsh JC
FAU - Turian, Julius V
AU  - Turian JV
FAU - Coleman, Joy L
AU  - Coleman JL
LA  - eng
PT  - Journal Article
DEP - 20090717
PL  - United States
TA  - Med Dosim
JT  - Medical dosimetry : official journal of the American Association of Medical 
      Dosimetrists
JID - 8908862
SB  - IM
MH  - Carcinoma/*radiotherapy
MH  - Humans
MH  - *Larynx
MH  - Oropharyngeal Neoplasms/*radiotherapy
MH  - Radiation Protection/methods
MH  - Radiotherapy Dosage
MH  - *Radiotherapy, Intensity-Modulated
MH  - Retrospective Studies
EDAT- 2009/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/02/26 00:00 [received]
PHST- 2009/05/28 00:00 [revised]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0958-3947(09)00054-5 [pii]
AID - 10.1016/j.meddos.2009.06.002 [doi]
PST - ppublish
SO  - Med Dosim. 2010 Autumn;35(3):214-9. doi: 10.1016/j.meddos.2009.06.002. Epub 2009 
      Jul 17.