PMID- 1993362
OWN - NLM
STAT- MEDLINE
DCOM- 19910319
LR  - 20190510
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 83
IP  - 2
DP  - 1991 Feb
TI  - Anti-idiotypes against anti-neutrophil cytoplasmic antigen autoantibodies in 
      normal human polyspecific IgG for therapeutic use and in the remission sera of 
      patients with systemic vasculitis.
PG  - 298-303
AB  - Anti-neutrophil cytoplasmic antigen (ANCA) activity was inhibited in 15 out of 21 
      sera from patients with acute systemic vasculitis following incubation with 
      normal polyspecific IgG for therapeutic use (IVIg). ANCA antibodies reacted with 
      IVIg through idiotypic-anti-idiotypic interactions, as shown in competitive 
      binding assays using F(ab')2 fragments from IVIg and affinity chromatography of 
      ANCA IgG on Sepharose-bound F(ab')2 fragments from IVIg. Co-incubation of sera 
      from patients with acute systemic vasculitis with paired autologous remission 
      stage sera also resulted in inhibition of ANCA activity in acute sera. Remission 
      sera contain IgM and IgG capable of interacting with beta and or alpha idiotypes 
      of ANCA IgG from acute sera. Anti-idiotypic IgM may account for the lack of 
      expression of ANCA activity in whole serum from patients in remission from 
      systemic vasculitis, which were found to contain high titres of ANCA IgG. These 
      observations suggest that remission of systemic vasculitis is associated with the 
      generation of anti-idiotypes against autoantibodies rather than the suppression 
      of production of ANCA autoantibodies. IVIg may modulate the activity of systemic 
      vasculitis in vivo.
FAU - Rossi, F
AU  - Rossi F
AD  - INSERM U28, Hopital Broussais, Paris, France.
FAU - Jayne, D R
AU  - Jayne DR
FAU - Lockwood, C M
AU  - Lockwood CM
FAU - Kazatchkine, M D
AU  - Kazatchkine MD
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/*analysis
MH  - Autoantibodies/*immunology
MH  - Autoimmune Diseases/immunology
MH  - Chromatography, Affinity
MH  - Cytoplasm/*immunology
MH  - Humans
MH  - Immunization, Passive
MH  - Immunoglobulin G/*immunology
MH  - Immunoglobulin M/immunology
MH  - Neutrophils/*immunology
MH  - Vasculitis/*immunology
PMC - PMC1535259
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
PMCR- 1992/02/01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
PHST- 1992/02/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2249.1991.tb05631.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1991 Feb;83(2):298-303. doi: 
      10.1111/j.1365-2249.1991.tb05631.x.