PMID- 19934610 OWN - NLM STAT- MEDLINE DCOM- 20100126 LR - 20201209 IS - 1598-9992 (Print) IS - 1598-9992 (Linking) VI - 54 IP - 5 DP - 2009 Nov TI - [Guidelines of treatment for non-bleeding peptic ulcer disease]. PG - 285-97 AB - Over the past century, since the introduction of non steroidal anti-inflammatory drugs (NSAID), antacid, histamine H2-receptor antagonists (H2RA), proton pump inhibitors (PPI), and discovery of Helicobacter pylori infection, the paradigm of peptic ulcer disease has changed with marked decrease in morbidity and mortality. However, peptic ulcer disease still occupies a position as a major health problem with increase of aged population and NSAIDs usage. In daily general practice, the management of peptic ulcer disease is directed according to the presence of bleeding or not. For non-bleeding peptic ulcer disease, proper acid suppression and the correction of underlying causes such as Helicobacter pylori infection and NSAID use is the main stay of treatment. Though a complete understanding of pathophysiology and a perfect treatment strategy are still a challenge, this guideline aims to provide practical recommendations based on evidences or consensus of experts through in-depth literature review and expert meeting. FAU - Cheung, Dae Young AU - Cheung DY AD - Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul National University Hospital, Seoul, Korea. FAU - Jung, Hwoon Yong AU - Jung HY FAU - Song, Ho June AU - Song HJ FAU - Jung, Sung Woo AU - Jung SW FAU - Jung, Hyun Chae AU - Jung HC CN - Korean College of Helicobacter and Upper Gastrointestinal Research CN - Korean Association of Gastroenterology LA - kor PT - Journal Article PT - Practice Guideline PL - Korea (South) TA - Korean J Gastroenterol JT - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi JID - 101189416 RN - 0 (Antacids) RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Anti-Ulcer Agents) RN - 0 (Histamine Antagonists) RN - 0 (Proton Pump Inhibitors) RN - U015TT5I8H (Bismuth) SB - IM MH - Antacids/toxicity MH - Anti-Inflammatory Agents, Non-Steroidal/toxicity MH - Anti-Ulcer Agents/therapeutic use MH - Bismuth/therapeutic use MH - Helicobacter Infections/diagnosis/drug therapy MH - Helicobacter pylori MH - Histamine Antagonists/therapeutic use MH - Humans MH - Peptic Ulcer/*drug therapy MH - Proton Pump Inhibitors/therapeutic use EDAT- 2009/11/26 06:00 MHDA- 2010/01/27 06:00 CRDT- 2009/11/26 06:00 PHST- 2009/11/26 06:00 [entrez] PHST- 2009/11/26 06:00 [pubmed] PHST- 2010/01/27 06:00 [medline] AID - 200911254 [pii] AID - 10.4166/kjg.2009.54.5.285 [doi] PST - ppublish SO - Korean J Gastroenterol. 2009 Nov;54(5):285-97. doi: 10.4166/kjg.2009.54.5.285.