PMID- 19935711
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20171116
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Linking)
VI  - 29
IP  - 7
DP  - 2010 Feb 18
TI  - Rictor is a novel target of p70 S6 kinase-1.
PG  - 1003-16
LID - 10.1038/onc.2009.401 [doi]
AB  - The rapamycin-insensitive companion of mammalian target of rapamycin (mTOR) 
      (Rictor) is a key member of mTOR complex-2 (mTORC2), which phosphorylates the AGC 
      kinases Akt/PKB, PKC and SGK1 at a C-terminal hydrophobic motif. We identified 
      several novel sites on Rictor that are phosphorylated, including Thr1135, which 
      is conserved across all vertebrates. Phosphorylation of this site on Rictor is 
      stimulated by amino acids and growth factors through a rapamycin-sensitive 
      signaling cascade. We demonstrate here that Rictor is a direct target of the 
      ribosomal protein S6 kinase-1 (S6K1). Rictor phosphorylation at Thr1135 does not 
      lead to major changes in mTORC2-kinase activity. However, phosphorylation of this 
      site turns over rapidly and mediates 14-3-3 binding to Rictor and mTORC2, 
      providing possibility for altered interactions of the complex. These findings 
      reveal an unexpected signaling input into mTORC2, which is regulated by amino 
      acids, growth factors and rapamycin.
FAU - Treins, C
AU  - Treins C
AD  - Signal Transduction Laboratory, Cancer Research UK London Research Institute, 
      London, UK.
FAU - Warne, P H
AU  - Warne PH
FAU - Magnuson, M A
AU  - Magnuson MA
FAU - Pende, M
AU  - Pende M
FAU - Downward, J
AU  - Downward J
LA  - eng
GR  - Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091123
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (14-3-3 Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Rapamycin-Insensitive Companion of mTOR Protein)
RN  - 0 (Transcription Factors)
RN  - 0 (rictor protein, rat)
RN  - 2ZD004190S (Threonine)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
SB  - IM
MH  - 14-3-3 Proteins/metabolism
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/chemistry/*metabolism
MH  - Cell Line
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/pharmacology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phosphorylation
MH  - Rapamycin-Insensitive Companion of mTOR Protein
MH  - Rats
MH  - Ribosomal Protein S6 Kinases, 70-kDa/*metabolism
MH  - Threonine
MH  - Transcription Factors/metabolism
EDAT- 2009/11/26 06:00
MHDA- 2010/03/13 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
AID - onc2009401 [pii]
AID - 10.1038/onc.2009.401 [doi]
PST - ppublish
SO  - Oncogene. 2010 Feb 18;29(7):1003-16. doi: 10.1038/onc.2009.401. Epub 2009 Nov 23.