PMID- 19936173 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20110714 LR - 20220321 IS - 1177-889X (Electronic) IS - 1177-889X (Linking) VI - 3 DP - 2009 Nov 3 TI - Attitudes toward medication and the clinical variables in schizophrenia: Structural equation models. PG - 305-9 AB - OBJECTIVE: Our study uses data from a large clinical trial to further dissect the contributors attitude toward antipsychotic medication measured with the Drug Attitude Inventory (DAI) in schizophrenia. METHOD: A total of 227 consecutive outpatients (140 males, 87 females) with schizophrenia or schizoaffective disorder according to DSM-IV criteria were evaluated. Structural equation models (SEM) were used to examine the relationship between attitudes toward medication as measured with the DAI and clinical variables assessed by Positive and Negative Syndrome Scale (PANSS) and Global Assessment of Functioning (GAF). RESULTS: Among four models, the data better fit a model in which attitudes toward medication (DAI-30) was predicted by PANSS Positive and Insight measures, and GAF (goodness-of-fit = 0.99). CONCLUSION: The data best fit a model where the most complex interaction of insight measures and positive symptoms does predict attitudes toward medication. FAU - Rossi, Alessandro AU - Rossi A AD - Department of Experimental Medicine at University of L'Aquila, Institute of Clinical Research 'Villa Serena' Department of Clinical Neuroscience, Citta S. Angelo, Italy; FAU - Pacifico, Roberta AU - Pacifico R FAU - Stratta, Paolo AU - Stratta P LA - eng PT - Journal Article DEP - 20091103 PL - New Zealand TA - Patient Prefer Adherence JT - Patient preference and adherence JID - 101475748 PMC - PMC2778420 OTO - NOTNLM OT - attitude toward medication OT - drug attitude inventory OT - structural equation models EDAT- 2009/11/26 06:00 MHDA- 2009/11/26 06:01 PMCR- 2009/11/03 CRDT- 2009/11/26 06:00 PHST- 2009/08/27 00:00 [received] PHST- 2009/11/26 06:00 [entrez] PHST- 2009/11/26 06:00 [pubmed] PHST- 2009/11/26 06:01 [medline] PHST- 2009/11/03 00:00 [pmc-release] AID - ppa-3-305 [pii] AID - 10.2147/ppa.s5590 [doi] PST - epublish SO - Patient Prefer Adherence. 2009 Nov 3;3:305-9. doi: 10.2147/ppa.s5590.