PMID- 19936782
OWN - NLM
STAT- MEDLINE
DCOM- 20100329
LR  - 20211020
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 456
IP  - 2
DP  - 2010 Feb
TI  - Soft tissue tumors associated with EWSR1 translocation.
PG  - 219-34
LID - 10.1007/s00428-009-0854-3 [doi]
AB  - The Ewing sarcoma breakpoint region 1 (EWSR1; also known as EWS) represents one 
      of the most commonly involved genes in sarcoma translocations. In fact, it is 
      involved in a broad variety of mesenchymal lesions which includes Ewing's 
      sarcoma/peripheral neuroectodermal tumor, desmoplastic small round cell 
      tumor,clear cell sarcoma, angiomatoid fibrous histiocytoma, extraskeletal myxoid 
      chondrosarcoma, and a subset of myxoid liposarcoma. The fusion products between 
      EWSR1 and partners usually results in fusion of the N-terminal 
      transcription-activating domain of EWSR1 and the C-terminal DNA-binding domain of 
      the fusion partner, eventually generating novel transcription factors. EWSR1 
      rearrangement can be visualized by the means of fluorescence in situ 
      hybridization (FISH). As soft tissue sarcomas represent a diagnostically 
      challenging group, FISH analysis is an extremely useful confirmatory diagnostic 
      tool. However, as in most instances a split-apart approach is used, the results 
      of molecular genetics must be evaluated in context with morphology.
FAU - Romeo, Salvatore
AU  - Romeo S
AD  - Department of Pathology, General Hospital of Treviso, Piazza Ospedale 1, Treviso, 
      Italy.
FAU - Dei Tos, Angelo P
AU  - Dei Tos AP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Calmodulin-Binding Proteins)
RN  - 0 (EWSR1 protein, human)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Calmodulin-Binding Proteins/*genetics
MH  - Gene Fusion
MH  - Humans
MH  - RNA-Binding Protein EWS
MH  - RNA-Binding Proteins/*genetics
MH  - Sarcoma/diagnosis/*genetics/pathology
MH  - Translocation, Genetic/*genetics
RF  - 124
EDAT- 2009/11/26 06:00
MHDA- 2010/03/30 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/08/20 00:00 [received]
PHST- 2009/10/17 00:00 [accepted]
PHST- 2009/10/07 00:00 [revised]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/03/30 06:00 [medline]
AID - 10.1007/s00428-009-0854-3 [doi]
PST - ppublish
SO  - Virchows Arch. 2010 Feb;456(2):219-34. doi: 10.1007/s00428-009-0854-3.