PMID- 19937088
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20211020
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Linking)
VI  - 98
IP  - 1
DP  - 2010 May
TI  - The cell-cycle kinetics of craniopharyngioma and its clinical significance.
PG  - 71-6
LID - 10.1007/s11060-009-0047-6 [doi]
AB  - Craniopharyngioma (CP) is a pathologically benign tumor with high incidence of 
      recurrence and poor prognosis. DNA ploidy, S-phase fraction (SPF), and G2 
      phase/mitosis phase + S phase (G2/M + S) measured by flow cytometry (FCM) have 
      been shown to correlate with cell cycle characteristics and clinical prognosis of 
      other tumors. By use of FCM and terminal deoxynucleotide transferase-mediated 
      dUTP nick end labeling (TUNEL) peroxidase, we compared DNA content, SPF, G2/M + 
      S, necrosis and apoptosis in non-recurrent and recurrent tumor cells of CP from 
      63 cases including 32 adamantine epitheliomas (AEs) and 31 squamous papillary 
      tumors (SPTs), and the ultrastructure of the CP cell was observed by transmission 
      electron microscopy. Although no obvious differences between DNA content and 
      necrosis and apoptosis rate were observed in subgroups of CPs, SPF and G2/M + S 
      for recurrent tumors were statistically higher than those for recurrence-free 
      tumors, and the recurrence rate of AE tumors is higher than that of SPT. 
      Therefore, CP cells are diploid, and SPF and G2/M + S are related to recurrence 
      of CP.
FAU - Xu, Jianguo
AU  - Xu J
AD  - Department of Neurosurgery, West China Hospital, Sichuan University, 37# 
      Guoxuexiang Street, 610041, Chengdu, People's Republic of China. 
      jianguoxu@mcwcums.com
FAU - You, Chao
AU  - You C
FAU - Zhou, Liangxue
AU  - Zhou L
FAU - Li, Qiang
AU  - Li Q
FAU - Zhou, Peizhi
AU  - Zhou P
FAU - Chen, Ni
AU  - Chen N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091124
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apoptosis/physiology
MH  - Cell Cycle/*physiology
MH  - Child
MH  - Child, Preschool
MH  - Craniopharyngioma/*pathology/*physiopathology/ultrastructure
MH  - Female
MH  - Flow Cytometry/methods
MH  - Follow-Up Studies
MH  - G2 Phase/physiology
MH  - Humans
MH  - In Situ Nick-End Labeling/methods
MH  - Male
MH  - Microscopy, Electron, Transmission/methods
MH  - Middle Aged
MH  - Pituitary Neoplasms/*pathology/*physiopathology/ultrastructure
MH  - Retrospective Studies
MH  - S Phase/physiology
MH  - Young Adult
EDAT- 2009/11/26 06:00
MHDA- 2010/09/09 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/05/29 00:00 [received]
PHST- 2009/10/26 00:00 [accepted]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - 10.1007/s11060-009-0047-6 [doi]
PST - ppublish
SO  - J Neurooncol. 2010 May;98(1):71-6. doi: 10.1007/s11060-009-0047-6. Epub 2009 Nov 
      24.