PMID- 19937404
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20211020
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 27
IP  - 4
DP  - 2010 Dec
TI  - Outcome of acute myeloid leukemia patients with hyperleukocytosis in Brazil.
PG  - 1254-9
LID - 10.1007/s12032-009-9367-9 [doi]
AB  - Acute myeloid leukemia (AML) with a high white blood cell (WBC) count at 
      presentation has been associated with an increased early mortality rate, usually 
      secondary to leukostasis. However, the value of the WBC count at which there is a 
      high risk of early death (ED) and the efficiency of supportive treatments remain 
      unclear. In this report, a series of 187 consecutive adult patients with AML in 
      our institution was reviewed. The outcome of 40 patients with WBC above 50x10(9) 
      L(-1) (hyperleukocytosis) was compared to 147 patients with a leukocyte count 
      lower than 50x10(9) L(-1). The group with hyperleukocytosis showed a 
      significantly shorter OS (P<0.0001) and a higher rate of ED (P=0.0008). Even when 
      the data from ED patients were removed from analysis, we still detected a shorter 
      OS in patients with hyperleukocytosis (P=0.0049), which suggests that high WBC 
      number influences long-term survival, and not only ED. We also observed higher 
      lactic dehydrogenase (LDH) and serum creatinine levels in the group of patients 
      with hyperleukocytosis (P=0.0003 and 0.0406, respectively). Besides considering 
      all the patients with ED, we could observe higher levels of lactic dehydrogenase, 
      a serum creatinine and nitrogen urea (P=0.0056, P=0.0008 and P<0.0001, 
      respectively). Pulmonary involvement was more frequent in patients with ED 
      (P=0.0277). In conclusion, hyperleukocytosis confers a poorer prognosis in 
      patients with AML.
FAU - Oliveira, L C O
AU  - Oliveira LC
AD  - Medical School of Ribeirao Preto, University of Sao Paulo, Rua Tenente Catao 
      Roxo, 2501, Ribeirao Preto, SP, 14051-140, Brazil. lucooliveira@yahoo.com.br
FAU - Romano, L G M
AU  - Romano LG
FAU - Prado-Junior, B P A
AU  - Prado-Junior BP
FAU - Covas, D T
AU  - Covas DT
FAU - Rego, E M
AU  - Rego EM
FAU - De Santis, G C
AU  - De Santis GC
LA  - eng
PT  - Journal Article
DEP - 20091125
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - AYI8EX34EU (Creatinine)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brazil
MH  - Creatinine/blood
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Leukemia, Myeloid, Acute/complications/*mortality/therapy
MH  - Leukocyte Count
MH  - Leukocytosis/*etiology/*mortality
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Young Adult
EDAT- 2009/11/26 06:00
MHDA- 2011/04/09 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - 10.1007/s12032-009-9367-9 [doi]
PST - ppublish
SO  - Med Oncol. 2010 Dec;27(4):1254-9. doi: 10.1007/s12032-009-9367-9. Epub 2009 Nov 
      25.