PMID- 19938595
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20091126
IS  - 1028-0987 (Print)
IS  - 1028-0987 (Linking)
VI  - 71
IP  - 2
DP  - 2009 Mar-Apr
TI  - [Study of specificity of fungistatic effect of trichothecene mycotoxins].
PG  - 57-62
AB  - In attempt to realize the purposeful search of highly sensitive and highly 
      specific microbial test-cultures the authors studied the ratio between selected 
      before species of yeast to the wide set of different mycotoxins including 
      macrocyclic trichothecenes (T-2 toxin, HT-2 toxin, T-2 triol, T-2 tetraol, NT-1 
      toxin, NT-2 toxin, fusarenon-X, diacetoxyscirpenol, deoxynivalenol, trichothecin, 
      trichothecolon, neosolaniol, verrucarin A, roridin A, roridin H, aflatoxins, B1, 
      B2, G1 and G2, sterigmatocystin, patulin, fusaric acid, ochratoxin A, zearalenon 
      and their derivatives). It was supposed to define borders of specific sensitivity 
      of test-cultures. The value of minimal inhibiting concentration (MIC) of 
      mycotoxins, which caused fungicide action in respect of the investigated yeast 
      strains, was used as the estimation criterion. Extremely few species with narrow 
      specific sensitivity to individual trichothecenes were found. Strains with group 
      sensitivity to investigated trichothecene mycotoxins (MCTC) were more widely 
      presented. Selectivity in respect of either simple (T-2 toxin), or MCTC 
      (verrucarin A, roridin A, roridin H) is traced for some species. Taxons with 
      mixed selectivity were discovered. Exceptionally high fungistatic activity was 
      characteristic of the investigated MCTC, T-2 toxin, trichothecin. Values of MCTC 
      for these substances in respect of more sensitive strains varied in the borders 
      of 0.03-0.1; 0.1-1.0 and 0.02-0.1 mcg/disk, correspondingly. It was less 
      expressed for diacetoxyscirpenol, deoxynivalenol, trichothecolon (0.8-5.0; 
      0.1-2.0 and 0.8-4.0 mcg/disk, correspondingly). The data obtained give reasons 
      for completing the bank of yeast test-cultures with wide potentialities of 
      mycotoxins indication in various food and fodder substrates.
FAU - Zaichenko, A M
AU  - Zaichenko AM
FAU - Nagornaia, S S
AU  - Nagornaia SS
FAU - Andrienko, E V
AU  - Andrienko EV
FAU - Tsyganenko, E S
AU  - Tsyganenko ES
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Ukraine
TA  - Mikrobiol Z
JT  - Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993)
JID - 9318954
RN  - 0 (Mycotoxins)
RN  - 0 (Trichothecenes)
SB  - IM
MH  - Biological Assay/*methods
MH  - Food Analysis/methods
MH  - Food Contamination/analysis
MH  - Microbial Sensitivity Tests
MH  - Mycotoxins/chemistry/toxicity
MH  - Structure-Activity Relationship
MH  - Trichothecenes/chemistry/*toxicity
MH  - Yeasts/*drug effects
EDAT- 2009/11/27 06:00
MHDA- 2010/04/07 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
PST - ppublish
SO  - Mikrobiol Z. 2009 Mar-Apr;71(2):57-62.