PMID- 19938698
OWN - NLM
STAT- MEDLINE
DCOM- 20091223
LR  - 20091126
IS  - 0004-1955 (Print)
IS  - 0004-1955 (Linking)
VI  - 71
IP  - 5
DP  - 2009 Sep-Oct
TI  - [Molecular biological approaches to differential diagnosis of skin melanoma].
PG  - 23-7
AB  - Twenty-two surgical biopsy specimens from patients with pigmented skin neoplasms 
      were studied. The patients were divided into 3 groups: 1) 11 patients who had a 
      histological verified diagnosis of melanoma; 2) 10 patients who were diagnosed as 
      having nevi with lentiginous melanocytic dysplasia; 3) 1 patient who had an 
      unclear diagnosis of presumptively, nevus with melanocytic dysplasia. By applying 
      fluorescence in situ hybridization (FISH) by means of a Vysis LSI RREBI/LSI 
      MYB/LSI CCNDI/ CEP 6 probe, the authors employed to test a new probe designed for 
      the genetic diagnosis of melanoma by FISH studies and confirmed in all the 22 
      patients the diagnosis previously made from the results of the routine 
      histological study and the presumptive diagnosis in 1 patient. Furthermore, it 
      should be noted that multiple genetic disorders were revealed in 3 patients (14% 
      of the total sample and 30% of the sample of patients diagnosed as having nevus 
      with lentiginous melanocytic dysplasia) in the absence of the morphological 
      criteria of melanoma. The patients with such disorders belong to a risk group and 
      need a more meticulous further follow-up.
FAU - Riazantseva, A A
AU  - Riazantseva AA
FAU - Zavalishina, L E
AU  - Zavalishina LE
FAU - Andreeva, Iu Iu
AU  - Andreeva IuIu
FAU - Frank, G A
AU  - Frank GA
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Arkh Patol
JT  - Arkhiv patologii
JID - 0370604
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Diagnosis, Differential
MH  - Female
MH  - *Genes, Neoplasm
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanoma/*metabolism/*pathology
MH  - Neoplasm Proteins/*biosynthesis
MH  - Predictive Value of Tests
MH  - Skin Neoplasms/*metabolism/*pathology
EDAT- 2009/11/27 06:00
MHDA- 2009/12/24 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2009/12/24 06:00 [medline]
PST - ppublish
SO  - Arkh Patol. 2009 Sep-Oct;71(5):23-7.