PMID- 19940230
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20181217
IS  - 1552-4604 (Electronic)
IS  - 0091-2700 (Linking)
VI  - 50
IP  - 3
DP  - 2010 Mar
TI  - An integrated glucose-insulin model to describe oral glucose tolerance test data 
      in healthy volunteers.
PG  - 246-56
LID - 10.1177/0091270009341185 [doi]
AB  - The extension of the previously developed integrated models for glucose and 
      insulin (IGI) to include the oral glucose tolerance test (OGTT) in healthy 
      volunteers could be valuable to better understand the differences between healthy 
      individuals and those with type 2 diabetes mellitus (T2DM). Data from an OGTT in 
      23 healthy volunteers were used. Analysis was based on the previously developed 
      intravenous model with extensions for glucose absorption and incretin effect on 
      insulin secretion. The need for additional structural components was evaluated. 
      The model was evaluated by simulation and a bootstrap. Multiple glucose and 
      insulin concentration peaks were observed in most individuals as well as 
      hypoglycemic episodes in the second half of the experiment. The OGTT data were 
      successfully described by the extended basic model. An additional control 
      mechanism of insulin on glucose production improved the description of the data. 
      The model showed good predictive properties, and parameters were estimated with 
      good precision. In conclusion, a previously presented integrated model has been 
      extended to describe glucose and insulin concentrations in healthy volunteers 
      following an OGTT. The characterization of the differences between the healthy 
      and diabetic stages in the IGI model could potentially be used to extrapolate 
      drug effect from healthy volunteers to T2DM.
FAU - Silber, Hanna E
AU  - Silber HE
AD  - Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden. 
      hanna.silber@farmbio.uu.se
FAU - Frey, Nicolas
AU  - Frey N
FAU - Karlsson, Mats O
AU  - Karlsson MO
LA  - eng
PT  - Journal Article
DEP - 20091125
PL  - England
TA  - J Clin Pharmacol
JT  - Journal of clinical pharmacology
JID - 0366372
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Administration, Oral
MH  - Blood Glucose/*metabolism
MH  - Glucose/*administration & dosage/*metabolism
MH  - Glucose Tolerance Test/*methods/statistics & numerical data
MH  - Humans
MH  - Insulin/blood/*metabolism
MH  - Insulin Secretion
MH  - Models, Biological
MH  - Reference Values
EDAT- 2009/11/27 06:00
MHDA- 2010/05/26 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - 0091270009341185 [pii]
AID - 10.1177/0091270009341185 [doi]
PST - ppublish
SO  - J Clin Pharmacol. 2010 Mar;50(3):246-56. doi: 10.1177/0091270009341185. Epub 2009 
      Nov 25.