PMID- 19941075
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20211020
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 37
IP  - 7
DP  - 2010 Oct
TI  - Functional monocyte chemoattractant protein-1 promoter -2518 polymorphism and 
      systemic lupus erythematosus: a meta-analysis.
PG  - 3421-6
LID - 10.1007/s11033-009-9932-5 [doi]
AB  - The monocyte chemoattractant protein-1 (MCP-1) promoter -2518 A/G polymorphism 
      has been reported inconsistently to be associated with systemic lupus 
      erythematosus (SLE) and lupus nephritis (LN). The aim of this study was to 
      explore whether the MCP-1 polymorphism confers susceptibility to SLE or LN. We 
      surveyed studies on the MCP-1 polymorphism and SLE or LN identified by MEDLINE or 
      manual searches. Meta-analysis was conducted on the AA genotype (recessive 
      effect), AA, and AG genotypes (dominant effect), AA versus GG (genotype 
      contrast), and on the A allele of MCP-1 in SLE and LN in each ethnic population 
      studied and on all subjects. Ten studies, which included 1,739 SLE patients and 
      1,680 controls, were included in our meta-analysis. These consisted of two 
      European, six Asian, one Latin American, and one mixed study. We did not find any 
      association between the MCP-1 -2518 A/G polymorphism and SLE in all subjects or 
      in ethnic groups. Meta-analysis also failed to reveal an association between the 
      MCP-1 -2518 A/G polymorphisms and LN. This meta-analysis on 3419 subjects 
      indicates that no association exists between the MCP-1 -2518 A/G polymorphism and 
      SLE or LN.
FAU - Lee, Young Ho
AU  - Lee YH
AD  - Division of Rheumatology, Department of Internal Medicine, Korea University 
      Medical Center, Korea University College of Medicine, Seoul, Korea. 
      lyhcgh@korea.ac.kr
FAU - Woo, Jin-Hyun
AU  - Woo JH
FAU - Choi, Sung Jae
AU  - Choi SJ
FAU - Ji, Jong Dae
AU  - Ji JD
FAU - Song, Gwan Gyu
AU  - Song GG
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20091126
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - Lupus Nephritis/genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2009/11/27 06:00
MHDA- 2011/01/11 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/08/08 00:00 [received]
PHST- 2009/11/16 00:00 [accepted]
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - 10.1007/s11033-009-9932-5 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2010 Oct;37(7):3421-6. doi: 10.1007/s11033-009-9932-5. Epub 2009 
      Nov 26.