PMID- 19941103 OWN - NLM STAT- MEDLINE DCOM- 20100202 LR - 20091126 IS - 1940-6029 (Electronic) IS - 1064-3745 (Linking) VI - 595 DP - 2010 TI - Review of murine dendritic cells: types, location, and development. PG - 21-42 LID - 10.1007/978-1-60761-421-0_2 [doi] AB - Dendritic cells (DCs) are key coordinators of the immune response, governing the choice between tolerance and immunity. DCs are professional antigen-presenting cells capable of presenting antigen on MHC molecules and priming CD4 and CD8 T-cell responses. They form a heterogeneous group of cells based on phenotype, location, and function. In this review, murine DCs will be discussed regarding their function with special emphasis on their tissue distribution. Recent findings on DC homeostasis during cancer progression will be presented. Finally, the developmental pathways leading to DC differentiation from their precursors will be summarized. FAU - Miloud, Tewfik AU - Miloud T AD - Division of Molecular Immunology, German Cancer Research Center DKFZ, Heidelberg, Germany. FAU - Hammerling, Gunter J AU - Hammerling GJ FAU - Garbi, Natalio AU - Garbi N LA - eng PT - Journal Article PT - Review PL - United States TA - Methods Mol Biol JT - Methods in molecular biology (Clifton, N.J.) JID - 9214969 SB - IM MH - Animals MH - Dendritic Cells/cytology/immunology/*physiology MH - Inflammation/immunology/metabolism MH - Mice MH - Neoplasms/immunology RF - 150 EDAT- 2009/11/27 06:00 MHDA- 2010/02/03 06:00 CRDT- 2009/11/27 06:00 PHST- 2009/11/27 06:00 [entrez] PHST- 2009/11/27 06:00 [pubmed] PHST- 2010/02/03 06:00 [medline] AID - 10.1007/978-1-60761-421-0_2 [doi] PST - ppublish SO - Methods Mol Biol. 2010;595:21-42. doi: 10.1007/978-1-60761-421-0_2.