PMID- 19941337
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20220318
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 41
IP  - 4
DP  - 2010 Apr
TI  - The 6-minute walk test as a new outcome measure in Duchenne muscular dystrophy.
PG  - 500-10
LID - 10.1002/mus.21544 [doi]
AB  - Walking abnormalities are prominent in Duchenne muscular dystrophy (DMD). We 
      modified the 6-minute walk test (6MWT) for use as an outcome measure in patients 
      with DMD and evaluated its performance in 21 ambulatory boys with DMD and 34 
      healthy boys, ages 4 to 12 years. Boys with DMD were tested twice, approximately 
      1 week apart; controls were tested once. The groups had similar age, height, and 
      weight. All tests were completed. Boys who fell recovered rapidly from falls 
      without injury. Mean +/- SD [range] 6-minute walk distance (6MWD) was lower in 
      boys with DMD than in controls (366 +/- 83 [125-481] m vs. 621 +/- 68 [479-754] 
      m; P < 0.0001; unpaired t-test). Test-retest correlation for boys with DMD was 
      high (r = 0.91). Stride length (R(2) = 0.89; P < 0.0001) was the major 
      determinant of 6MWD for both boys with DMD and controls. A modified 6MWT is 
      feasible and safe, documents disease-related limitations on ambulation, is 
      reproducible, and offers a new outcome measure for DMD natural history and 
      therapeutic trials.
FAU - McDonald, Craig M
AU  - McDonald CM
AD  - Department of Physical Medicine and Rehabilitation, University of California 
      Davis School of Medicine, Sacramento, California, 95817, USA. 
      cmmcdonald@ucdavis.edu
FAU - Henricson, Erik K
AU  - Henricson EK
FAU - Han, Jay J
AU  - Han JJ
FAU - Abresch, R Ted
AU  - Abresch RT
FAU - Nicorici, Alina
AU  - Nicorici A
FAU - Elfring, Gary L
AU  - Elfring GL
FAU - Atkinson, Leone
AU  - Atkinson L
FAU - Reha, Allen
AU  - Reha A
FAU - Hirawat, Samit
AU  - Hirawat S
FAU - Miller, Langdon L
AU  - Miller LL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Exercise Test/*methods/standards
MH  - Humans
MH  - Male
MH  - Muscular Dystrophy, Duchenne/*diagnosis/*physiopathology
MH  - Outcome Assessment, Health Care
MH  - Reproducibility of Results
MH  - Time Factors
MH  - Treatment Outcome
MH  - Walking/*physiology
EDAT- 2009/11/27 06:00
MHDA- 2010/04/13 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
AID - 10.1002/mus.21544 [doi]
PST - ppublish
SO  - Muscle Nerve. 2010 Apr;41(4):500-10. doi: 10.1002/mus.21544.