PMID- 19941365
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20161125
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 38
IP  - 7
DP  - 2010 Jul
TI  - Imprint cytologic features of chromophobe renal cell carcinoma morphologically 
      resembling renal oncocytoma: is this an oncocytic variant of chromophobe renal 
      cell carcinoma?
PG  - 509-13
LID - 10.1002/dc.21256 [doi]
AB  - In this article, we report a case of 76-year-old woman with a rare variant of 
      chromophobe renal cell carcinoma (CRCC). Cytologically, renal tumor cells 
      obtained from imprint cytology were isolated or arranged in small or monotonous 
      population cells with abundant granular cytoplasm. Neoplastic cells showed 
      regular and uniformly shaped small round to oval nuclei with smooth margin. 
      Binucleation was occasionally seen. Immunocytochemically, the cytoplasm of almost 
      all tumor cells was diffusely positive for vimentin and CK 7. Histologically, the 
      cytoplasm was abundant granular eosinophilic and composed of solid cell sheets or 
      pseudoacinar structures. Additionally, tumor cells showed infiltration into some 
      small renal veins covered by a single layer of endothelial cells. These 
      cytological and histological features entirely resembled those of renal 
      oncocytoma. We performed the analysis of von Hippel-Lindau (VHL) gene mutation, 
      3p loss of heterozygosity (LOH), and fluorescence in situ hybridization (FISH) on 
      chromosomes 7, 10, 13, 17, and 21. As a result, we confirmed monosomy of 
      chromosomes 7, 10, 13, and 17, and these findings corresponded to the diagnosis 
      of CRCC. Finally, we present a case of renal tumor morphologically resembling 
      renal oncocytoma but genetically showing CRCC. We suggest that oncocytic variant 
      of CRCC may actually exist.
CI  - (c) 2009 Wiley-Liss, Inc.
FAU - Yamaguchi, Tadanori
AU  - Yamaguchi T
AD  - Department of Cytopathology, Ayabe City Hospital, Ayabe, Kyoto, Japan. 
      yamaguchi.t@ayabe-hsp.or.jp
FAU - Kuroda, Naoto
AU  - Kuroda N
FAU - Imamura, Yoshiaki
AU  - Imamura Y
FAU - Hes, Ondrej
AU  - Hes O
FAU - Michal, Michal
AU  - Michal M
FAU - Sima, Radek
AU  - Sima R
FAU - Nakayama, Keizou
AU  - Nakayama K
FAU - Sato, Nodoka
AU  - Sato N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
RN  - EC 6.3.2.- (VHL protein, human)
SB  - IM
MH  - Adenoma, Oxyphilic/genetics/*pathology
MH  - Aged
MH  - Carcinoma, Renal Cell/genetics/*pathology
MH  - Chromosomes, Human/genetics
MH  - Cytological Techniques/*methods
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney/*pathology
MH  - Kidney Neoplasms/genetics/*pathology
MH  - Loss of Heterozygosity/genetics
MH  - Mutation/genetics
MH  - Von Hippel-Lindau Tumor Suppressor Protein/genetics
EDAT- 2009/11/27 06:00
MHDA- 2010/09/16 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.1002/dc.21256 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2010 Jul;38(7):509-13. doi: 10.1002/dc.21256.