PMID- 19941959
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20150831
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 61
IP  - 4
DP  - 2010 Apr
TI  - Altered regulation of glutamate release and decreased functional activity and 
      expression of GLT1 and GLAST glutamate transporters in the hippocampus of 
      adolescent rats perinatally exposed to Delta(9)-THC.
PG  - 334-41
LID - 10.1016/j.phrs.2009.11.008 [doi]
AB  - The long-term effects of perinatal Delta(9)-tetrahydrocannabinol (Delta(9)-THC) 
      exposure - from gestational day (GD) 15 to postnatal day (PND) 9 - on hippocampal 
      glutamatergic neurotransmission were studied in slices from the 40-day-old 
      offspring of Delta(9)-THC exposed (Delta(9)-THC-rats) and vehicle-exposed 
      (control) dams. Basal and in K+-evoked endogenous hippocampal glutamate outflow 
      were both significantly decreased in Delta(9)-THC-rats. The effect of short 
      Delta(9)-THC exposure (0.1microM) on K(+)-evoked glutamate release disclosed a 
      loss of the stimulatory effect of Delta(9)-THC on hippocampal glutamate release 
      in Delta(9)-THC-rats, but not in controls. In addition, l-[(3)H]-glutamate uptake 
      was significantly lower in hippocampal slices from Delta(9)-THC-rats, where a 
      significant decrease in glutamate transporter 1 (GLT1) and glutamate/aspartate 
      transporter (GLAST) protein was also detected. Collectively, these data 
      demonstrate that perinatal exposure to cannabinoids induces long-term impairment 
      in hippocampal glutamatergic neurotransmission that persist into adolescence.
CI  - Copyright 2009. Published by Elsevier Ltd.
FAU - Castaldo, Pasqualina
AU  - Castaldo P
AD  - Department of Neuroscience, University Politecnica delle Marche, Ancona, Italy.
FAU - Magi, Simona
AU  - Magi S
FAU - Cataldi, Mauro
AU  - Cataldi M
FAU - Arcangeli, Sara
AU  - Arcangeli S
FAU - Lariccia, Vincenzo
AU  - Lariccia V
FAU - Nasti, Annamaria Assunta
AU  - Nasti AA
FAU - Ferraro, Luca
AU  - Ferraro L
FAU - Tomasini, Maria Cristina
AU  - Tomasini MC
FAU - Antonelli, Tiziana
AU  - Antonelli T
FAU - Cassano, Tommaso
AU  - Cassano T
FAU - Cuomo, Vincenzo
AU  - Cuomo V
FAU - Amoroso, Salvatore
AU  - Amoroso S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091124
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Excitatory Amino Acid Transporter 1)
RN  - 0 (Excitatory Amino Acid Transporter 2)
RN  - 0 (SLC1A3 protein, human)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 7J8897W37S (Dronabinol)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Dronabinol/*toxicity
MH  - Excitatory Amino Acid Transporter 1/*metabolism
MH  - Excitatory Amino Acid Transporter 2/*metabolism
MH  - Female
MH  - Glutamic Acid/*metabolism
MH  - Hippocampus/*drug effects/metabolism
MH  - In Vitro Techniques
MH  - Potassium/pharmacology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Synaptic Transmission/*drug effects
EDAT- 2009/11/28 06:00
MHDA- 2010/06/18 06:00
CRDT- 2009/11/28 06:00
PHST- 2009/07/20 00:00 [received]
PHST- 2009/11/17 00:00 [revised]
PHST- 2009/11/17 00:00 [accepted]
PHST- 2009/11/28 06:00 [entrez]
PHST- 2009/11/28 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - S1043-6618(09)00277-1 [pii]
AID - 10.1016/j.phrs.2009.11.008 [doi]
PST - ppublish
SO  - Pharmacol Res. 2010 Apr;61(4):334-41. doi: 10.1016/j.phrs.2009.11.008. Epub 2009 
      Nov 24.