PMID- 19942750
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20220330
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 130
IP  - 4
DP  - 2009 Oct
TI  - CCR2, MCP-1, SDF-1a & DC-SIGN gene polymorphisms in HIV-1 infected patients with 
      & without tuberculosis.
PG  - 444-50
AB  - BACKGROUND & OBJECTIVES: Variability in the clinical outcome of persons exposed 
      to and infected with HIV-1 and tuberculosis (TB) is determined by multiple 
      factors including host genetic variations. The aim of the present study was to 
      find out whether chemokine, chemokine receptor and DC-SIGN gene polymorphisms 
      were associated with susceptibility or resistance to HIV and HIV-TB in south 
      India. METHODS: CCR2 V64I (G/A), monocyte chemoattractant protein-1 (MCP-1) -2518 
      A/G, stromal cell derived factor-1alpha; (SDF-1alpha) 3'UTR G/A and DC-SIGN gene 
      polymorphisms were studied by polymerase chain reaction based methods in HIV-1 
      infected patients without TB (n=151), with pulmonary TB (PTB) (n=81) and 
      extrapulmonary TB (n=31), 155 PTB patients without HIV and 206 healthy controls. 
      RESULTS: The genotype frequencies of CCR2 V64I, MCP-1 -2518 and DC-SIGN 
      polymorphisms did not differ significantly between the study groups. A 
      significantly increased frequency of GG genotype of SDF-1alpha polymorphism was 
      observed among HIV+PTB+ patients compared to healthy controls (P=0.009, 
      Pc=0.027). INTERPRETATION & CONCLUSIONS: Our data suggest that GG genotype of 
      SDF-1alpha 3'UTR polymorphism may be associated with susceptibility to PTB in 
      HIV-1 infected patients. A better understanding of genetic factors that are 
      associated with TB could help target preventive strategies to those HIV patients 
      likely to develop tuberculosis.
FAU - Alagarasu, K
AU  - Alagarasu K
AD  - Tuberculosis Research Centre (ICMR), Chennai, India.
FAU - Selvaraj, P
AU  - Selvaraj P
FAU - Swaminathan, S
AU  - Swaminathan S
FAU - Raghavan, S
AU  - Raghavan S
FAU - Narendran, G
AU  - Narendran G
FAU - Narayanan, P R
AU  - Narayanan PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
RN  - 0 (3' Untranslated Regions)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Adult
MH  - Cell Adhesion Molecules/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Chemokine CXCL12/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - *HIV Infections/complications/genetics
MH  - HIV-1
MH  - Humans
MH  - India
MH  - Lectins, C-Type/*genetics
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Receptors, CCR2/*genetics
MH  - Receptors, Cell Surface/*genetics
MH  - Treatment Outcome
MH  - *Tuberculosis/etiology/genetics
MH  - Young Adult
EDAT- 2009/11/28 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/11/28 06:00
PHST- 2009/11/28 06:00 [entrez]
PHST- 2009/11/28 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
PST - ppublish
SO  - Indian J Med Res. 2009 Oct;130(4):444-50.